Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.
Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.
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DOI：
10.1371/journal.pone.0019422
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发表时间：
2011-04-29
期刊：
影响因子：
3.7
通讯作者：
Chitnis CE
中科院分区：
文献类型：
--
作者：
Mayor A;Hafiz A;Bassat Q;Rovira-Vallbona E;Sanz S;Machevo S;Aguilar R;Cisteró P;Sigaúque B;Menéndez C;Alonso PL;Chitnis CE
严重疟疾部分归因于恶性疟原虫感染的红细胞（IE）在重要宿主器官的微血管中的隔离。鉴定恶性疟原虫与严重疟疾相关的细胞粘附表型可能会导致对抗危及生命的疟疾的新策略的发展。46个恶性疟原虫分离株从莫桑比克5岁以下儿童严重疟疾（病例）进行了检查，并比较了46个分离株从性别和年龄匹配的莫桑比克儿童单纯性疟疾（对照）。细胞粘附特性，如血小板介导的凝集，玫瑰花结和粘附纯化的受体（CD36，ICAM 1和gC1qR），这些匹配对之间进行了比较，通过非参数检验。严重疟疾最常见的临床表现是虚脱。与匹配的对照组相比，病例组（P = 0.019）、出现虚脱的儿童（P = 0.049）和严重贫血的儿童（P = 0.025）中血小板介导的凝集的患病率更高。 玫瑰花结和gC1qR粘附的患病率也较高的情况下，严重贫血和多次癫痫发作，分别（P = 0.045，在这两种情况下），比对照组。 这些数据表明血小板介导的聚集，玫瑰花结和粘附到gC1qR的严重疟疾的发病机制中的作用。抑制这些细胞粘附表型可能会减少严重疟疾结局的发生或改善其预后。
Severe malaria has been attributed partly to the sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the microvasculature of vital host organs. Identification of P. falciparum cytoadherence phenotypes that are associated with severe malaria may lead to the development of novel strategies against life-threatening malaria. Forty-six P. falciparum isolates from Mozambican children under 5 years of age with severe malaria (cases) were examined and compared to 46 isolates from sex and age matched Mozambican children with uncomplicated malaria (controls). Cytoadherence properties such as platelet-mediated clumping, rosetting and adhesion to purified receptors (CD36, ICAM1 and gC1qR), were compared between these matched pairs by non-parametric tests. The most common clinical presentation associated with severe malaria was prostration. Compared to matched controls, prevalence of platelet-mediated clumping was higher in cases (P = .019), in children presenting with prostration (P = .049) and in children with severe anaemia (P = .025). Prevalence of rosetting and gC1qR adhesion were also higher in isolates from cases with severe anemia and multiple seizures, respectively (P = .045 in both cases), than in controls. These data indicate a role for platelet-mediated clumping, rosetting and adhesion to gC1qR in the pathogenesis of severe malaria. Inhibition of these cytoadherence phenotypes may reduce the occurrence or improve the prognosis of severe malaria outcomes.
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影响因子：
6.7
作者：
Biswas AK;Hafiz A;Banerjee B;Kim KS;Datta K;Chitnis CE
通讯作者：
Chitnis CE
影响因子：
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影响因子：
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作者：
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