IL-36 cytokines in autoimmunity and inflammatory disease.

IL-36 cytokines in autoimmunity and inflammatory disease.
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DOI:
10.18632/oncotarget.22814
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发表时间:
2018-01-05
期刊:
影响因子:
--
通讯作者:
Liu D
Liu D
中科院分区:
其他
文献类型:
--
作者:
Ding L;Wang X;Hong X;Lu L;Liu D

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白介素36(IL-36)细胞因子包括IL-36α、IL-36β、IL-36γ和IL-36Ra,属于IL-1家族,对角质形成细胞、滑膜细胞、树突状细胞和T细胞等多种靶细胞发挥促炎作用。新的证据表明 IL-36 在许多炎症性疾病的发病机制中发挥着作用。在此,我们对IL-36家族细胞因子的激活及其在自身免疫和炎症性疾病中的参与进行简要综述,这将为理解IL-36家族细胞因子在自身免疫和炎症性疾病病理生理学中的功能提供进一步的见解。
The inteleukin-36 (IL-36) cytokines include IL-36α, IL-36β, IL-36γ and IL-36Ra, which belong to the IL-1 family and exert pro-inflammatory effects on various target cells such as keratinocytes, synoviocytes, dendritic cells and T cells. Emerging evidence has suggested a role of IL-36 in the pathogenesis of many inflammatory diseases. Here, we provide a brief review on the activation of IL-36 family cytokines and their involvement in autoimmunity and inflammatory diseases, which will provide further insights in understanding the functions of IL-36 family cytokines in the pathophysiology of autoimmunity and inflammatory diseases.
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