Responses of the rat basal ganglia neurotensin systems to low doses of methamphetamine.
Responses of the rat basal ganglia neurotensin systems to low doses of methamphetamine.
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DOI：
10.1007/s00213-014-3468-7
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发表时间：
2014-08
影响因子：
3.4
通讯作者：
Hanson, Glen R.
中科院分区：
文献类型：
--
作者：
Alburges, Mario E.;Hoonakker, Amanda J.;Cordova, Nathaniel M.;Robson, Christina M.;McFadden, Lisa M.;Martin, Amber L.;Hanson, Glen R.
以模拟滥用相关的暴饮暴食模式的方式给予高剂量的甲基苯丙胺，可减少NT的释放，并通过D1机制导致其在锥体外系结构中的积累和NT水平的升高。这些发现与冰毒治疗使用的相关性需要研究。检测了低剂量冰毒(与用于治疗的冰毒相当)对基底节NT系统的影响，并与高剂量冰毒和自身给药的影响进行了比较。给大鼠注射生理盐水或低剂量冰毒(0.25、0.50或1.00 mg/kg/sc)4次(间隔2小时)。在DA拮抗剂的研究中，动物在冰毒或生理盐水处理前15分钟用D_1(SCH23390)或D_2(乙硫氯必利)拮抗剂处理。末次注射后5~48h处死大鼠。0.25和0.50剂量的冰毒，而不是1.00 mg/kg的冰毒能迅速和短暂地降低所研究的所有基底节结构中NTLI的浓度。在后背侧纹状体，低剂量冰毒引起的NT水平下降主要是由D2刺激引起的，但在其他基底节区域，NT反应既需要D2刺激，也需要D1刺激。本研究的一个新发现是，与滥用模拟高剂量冰毒相反，具有治疗意义的低剂量冰毒治疗降低了NT组织水平，可能反映了NT释放的增加和基底节结构中这种神经肽水平的短期枯竭。并对其可能的意义进行了讨论。
Administration of high doses of methamphetamine (METH) in a manner mimicking the bingeing patterns associated with abuse, reduces NT release and causes its accumulation and elevated NT levels in extrapyramidal structures by a D1 mechanism. The relevance of these findings to the therapeutic use of METH needs to be studied. The effect of low doses (comparable to that used for therapy) of METH on basal ganglia NT systems was examined and compared to high-dose and self-administration effects previously reported. Rats were injected four times (2-h intervals) with either saline or low doses of METH (0.25, 0.50 or 1.00 mg/kg/s.c.). For the DA antagonist studies, animals were pretreated with a D1 (SCH23390) or D2 (eticlopride) antagonist 15 min prior to METH or saline treatments. Rats were sacrificed 5–48 h after last injection. METH at doses of 0.25 and 0.50, but not 1.00 mg/kg rapidly and briefly decreased NTLI concentration in all basal ganglia structures studied. In the posterior dorsal striatum, the reduction in NT level after low-dose METH appeared to be caused principally by D2 stimulation, but both D2 and D1 stimulation were required for the NT responses in the other basal ganglia regions. A novel finding from the present study was that opposite to abuse-mimicking high doses of METH, the therapeutically relevant low-dose METH treatment reduced NT tissue levels likely reflecting an increase in NT release and a short-term depletion of the levels of this neuropeptide in basal ganglia structures. The possible significance is discussed.
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影响因子：
4.7
作者：
Alburges, ME;Keefe, KA;Hanson, GR
通讯作者：
Hanson, GR
DOI：
10.1124/jpet.110.176610
发表时间：
2011-03-01
影响因子：
3.5
作者：
Frankel, Paul S.;Hoonakker, Amanda J.;Hanson, Glen R.
通讯作者：
Hanson, Glen R.
影响因子：
3.4
作者：
CASTEL, MN;MORINO, P;HOKFELT, T
通讯作者：
HOKFELT, T
影响因子：
--
作者：
Ferraro, Luca;Tomasini, Maria C.;Antonelli, Tiziana
通讯作者：
Antonelli, Tiziana
影响因子：
2.9
作者：
Alburges, ME;Keefe, KA;Hanson, GR
通讯作者：
Hanson, GR