Association of Fcγ receptor IIB polymorphism with cryptococcal meningitis in HIV-uninfected Chinese patients.
Association of Fcγ receptor IIB polymorphism with cryptococcal meningitis in HIV-uninfected Chinese patients.
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DOI：
10.1371/journal.pone.0042439
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Weng XH
中科院分区：
文献类型：
--
作者：
Hu XP;Wu JQ;Zhu LP;Wang X;Xu B;Wang RY;Ou XT;Weng XH
人Fcγ受体（FcγRs）作为免疫系统的重要调节因子，在多种感染性疾病的发病机制中发挥重要作用。本研究的目的是确定FCGR多态性和隐球菌脑膜炎之间的关联。在本病例对照遗传关联研究中，我们采用多重SNaPshot技术对117例隐球菌性脑膜炎患者和190例健康对照者的低亲和力Fcγ R的4种功能多态性进行了基因分型，包括FCGR 2A 131 H/R、FCGR 3A 158 F/V、FCGR 3B NA 1/NA 2和FCGR 2B 232 I/T。117例隐球菌性脑膜炎患者中，59例有易感因素。与对照组相比，隐球菌性脑膜炎患者FCGR 2B 232 I/I基因型高表达（OR = 1.652，95%CI [1.02-2.67]; P = 0.039），FCGR 2B 232 I/T基因型低表达（OR = 0.542，95%CI [0.33-0.90]; P =0.016）。 在无易感因素的隐球菌脑膜炎患者中，FCGR 2B 232 I/I基因型检出率也高于对照组（OR = 1.958，95%CI [1.05-3.66]; P = 0.033），FCGR 2B 232 I/T基因型检出率也低于对照组（OR = 0.467，95%CI [0.24-0.91]; P = 0.023）。 FCGR 2A 131 H/R、FCGR 3A 158 F/V和FCGR 3BNA 1/NA 2基因型频率在两组间差异无统计学意义。我们首次发现隐球菌脑膜炎与FCGR 2B 232 I/T基因型之间存在相关性，提示FcγRIIB可能在HIV未感染者中枢神经系统隐球菌感染中起重要作用。
As important regulators of the immune system, the human Fcγ receptors (FcγRs) have been demonstrated to play important roles in the pathogenesis of various infectious diseases. The aim of the present study was to identify the association between FCGR polymorphisms and cryptococcal meningitis. In this case control genetic association study, we genotyped four functional polymorphisms in low-affinity FcγRs, including FCGR2A 131H/R, FCGR3A 158F/V, FCGR3B NA1/NA2, and FCGR2B 232I/T, in 117 patients with cryptococcal meningitis and 190 healthy controls by multiplex SNaPshot technology. Among the 117 patients with cryptococcal meningitis, 59 had predisposing factors. In patients with cryptococcal meningitis, the FCGR2B 232I/I genotype was over-presented (OR = 1.652, 95% CI [1.02–2.67]; P = 0.039) and the FCGR2B 232I/T genotype was under-presented (OR = 0.542, 95% CI [0.33–0.90]; P = 0.016) in comparison with control group. In cryptococcal meningitis patients without predisposing factors, FCGR2B 232I/I genotype was also more frequently detected (OR = 1.958, 95% CI [1.05–3.66]; P = 0.033), and the FCGR2B 232I/T genotype was also less frequently detected (OR = 0.467, 95% CI [0.24–0.91]; P = 0.023) than in controls. No significant difference was found among FCGR2A 131H/R, FCGR3A 158F/V, and FCGR3B NA1/NA2 genotype frequencies between patients and controls. We found for the first time associations between cryptococcal meningitis and FCGR2B 232I/T genotypes, which suggested that FcγRIIB might play an important role in the central nervous system infection by Cryptococcus in HIV-uninfected individuals.
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影响因子：
3.7
作者：
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通讯作者：
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