fMRI evidence of improved visual function in patients with progressive retinitis pigmentosa by eye-movement training.
fMRI evidence of improved visual function in patients with progressive retinitis pigmentosa by eye-movement training.
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DOI：
10.1016/j.nicl.2014.02.007
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Seiyama A
中科院分区：
文献类型：
--
作者：
Yoshida M;Origuchi M;Urayama S;Takatsuki A;Kan S;Aso T;Shiose T;Sawamoto N;Miyauchi S;Fukuyama H;Seiyama A
为了评估通过眼动训练(EMT)提高阅读能力的进行性视网膜色素变性(RP)患者视觉加工的变化，我们在EMT前后进行了功能磁共振成像(FMRI)。研究对象为6例视网膜色素变性所致双眼向心性收缩患者和6例正常志愿者。患者接受EMT治疗，每天5分钟，持续8~10个月。FMRI数据是在受试者执行阅读任务时在3.0特斯拉扫描仪上采集的。在单独的实验中(在功能磁共振扫描之前)，阅读的视觉表现是通过5分钟内正确阅读的字母数量来衡量的。EMT前，患者初级视皮层激活面积为对照组的48.8%。5分钟内正确阅读的字母数是正常志愿者的36.6%。EMT后，患者的激活区域没有改变或略有减少，但6例患者中有5例阅读成绩提高，是正常志愿者的46.6%(p<；P<；0.05)。EMT后，所有患者的额叶视野(FEF)活动都有所增加；然而，只有阅读能力改善较大的患者才能观察到顶叶眼场(PEF)活动的增加。EMT后患者阅读能力的提高被认为是FEF和PEF活动增加的结果，FEF和PEF在注意力和工作记忆以及眼动调节中起着重要作用。我们对隧道视力患者进行了fMRI测量。训练后，所有患者的FEF活性均有升高。患者阅读能力的高度改善表明PEF的活动增加。阅读能力的提高被认为是FEF和PEF活动的增加。
To evaluate changes in the visual processing of patients with progressive retinitis pigmentosa (RP) who acquired improved reading capability by eye-movement training (EMT), we performed functional magnetic resonance imaging (fMRI) before and after EMT. Six patients with bilateral concentric contraction caused by pigmentary degeneration of the retina and 6 normal volunteers were recruited. Patients were given EMT for 5 min every day for 8–10 months. fMRI data were acquired on a 3.0-Tesla scanner while subjects were performing reading tasks. In separate experiments (before fMRI scanning), visual performances for readings were measured by the number of letters read correctly in 5 min. Before EMT, activation areas of the primary visual cortex of patients were 48.8% of those of the controls. The number of letters read correctly in 5 min was 36.6% of those by the normal volunteers. After EMT, the activation areas of patients were not changed or slightly decreased; however, reading performance increased in 5 of 6 patients, which was 46.6% of that of the normal volunteers (p< 0.05). After EMT, increased activity was observed in the frontal eye fields (FEFs) of all patients; however, increases in the activity of the parietal eye fields (PEFs) were observed only in patients who showed greater improvement in reading capability. The improvement in reading ability of the patients after EMT is regarded as an effect of the increased activity of FEF and PEF, which play important roles in attention and working memory as well as the regulation of eye movements. We made fMRI measurements for tunnel vision patients. After training, increases in activity of FEF were observed in all patients. Patients' highly improved reading capability showed increased activity of PEF. Improvement in reading is regarded as increased activity of FEF and PEF.
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影响因子：
3.7
作者：
Makiyama Y;Ooto S;Hangai M;Takayama K;Uji A;Oishi A;Ogino K;Nakagawa S;Yoshimura N
通讯作者：
Yoshimura N
影响因子：
1.4
作者：
MCMAHON, TT;HANSEN, M;VIANA, MAG
通讯作者：
VIANA, MAG
影响因子：
5.7
作者：
Silk, Timothy J.;Bellgrove, Mark A.;Cunnington, Ross
通讯作者：
Cunnington, Ross
影响因子：
4.4
作者：
Klauke, Susanne;Goertz, Michael;Wachtler, Thomas
通讯作者：
Wachtler, Thomas
影响因子：
3.7
作者：
Masuda, Yoichiro;Dumoulin, Serge O.;Wandell, Brian A.
通讯作者：
Wandell, Brian A.