Thick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSR.
Thick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSR.
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DOI：
10.1007/s00424-008-0607-1
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发表时间：
2009-05
影响因子：
4.5
通讯作者：
Friedman, Peter A.
中科院分区：
文献类型：
--
作者：
Gamba, Gerardo;Friedman, Peter A.
亨利氏袢的粗升支是一个肾单位段，对稀尿和浓尿的形成至关重要。这种能力是由功能偶联的蛋白质组成的顶端Na+：K+：2Cl-共转运蛋白，K+通道和基底外侧Cl-通道介导的电中性盐吸收的财团。在粗大的上行肢体中，盐的吸收受到钙敏感受体的重要调节。遗传或药理学破坏损害任何这些蛋白质的功能导致巴特综合征。粗的升支也是Ca ~（2+）、Mg ~（2+）吸收的重要部位。钙敏感受体激活抑制甲状旁腺激素诱导的细胞Ca 2+吸收，以及被动的细胞旁Ca 2+转运。本综述讨论了这些功能及其遗传和分子调控。
The thick ascending limb of Henle's loop is a nephron segment that is vital to the formation of dilute and concentrated urine. This ability is accomplished by a consortium of functionally coupled proteins consisting of the apical Na+:K+:2Cl– co-transporter, the K+ channel, and basolateral Cl– channel that mediate electroneutral salt absorption. In thick ascending limbs, salt absorption is importantly regulated by the calcium-sensing receptor. Genetic or pharmacological disruption impairing the function of any of these proteins results in Bartter syndrome. The thick ascending limb is also an important site of Ca2+ and Mg2+ absorption. Calcium-sensing receptor activation inhibits cellular Ca2+ absorption induced by parathyroid hormone, as well as passive paracellular Ca2+ transport. The present review discusses these functions and their genetic and molecular regulation.
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影响因子：
3
作者：
Bettinelli, A;Ciarmatori, S;Casari, G
通讯作者：
Casari, G
影响因子：
6.2
作者：
Butters, RR;Chattopadhyay, N;Brown, EM
通讯作者：
Brown, EM
影响因子：
19.6
作者：
BURG, MB
通讯作者：
BURG, MB
影响因子：
--
作者：
BESSEGHIR, K;TRIMBLE, ME;STONER, L
通讯作者：
STONER, L
影响因子：
4.8
作者：
CHEN, CJ;BARNETT, JV;BROWN, EM
通讯作者：
BROWN, EM