Gene-x-environment analysis supports protective effects of eveningness chronotype on self-reported and actigraphy-derived sleep duration among those who always work night shifts in the UK Biobank.
Gene-x-environment analysis supports protective effects of eveningness chronotype on self-reported and actigraphy-derived sleep duration among those who always work night shifts in the UK Biobank.
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作者：
之前的研究表明，夜猫子的生物钟类型与对夜班工作的耐受性更高有关，这表明，夜班工作而不影响健康的能力可能部分取决于生物钟是否针对这些时间进行了优化。随着时间的推移，睡眠类型会受到环境因素的影响，健康夜班工人的相对晚睡率较高是否反映了睡眠类型对健康的调节或中介作用，目前尚不清楚。为了解决这些问题，我们开展了一项全基因组关联研究，并利用多基因评分（PGS）作为时间型的时间不变测量。在英国生物银行（2006-2018）的53211名工人的样本中，我们重点研究了夜班工作对睡眠时间的影响，这是夜班工作对健康产生不利影响的一个渠道。我们的问题是，更倾向于晚睡是否会促进夜班工作的耐受性。结果表明，与从不上夜班的人相比，定期上夜班的人每晚自我报告的睡眠时间减少了13分钟（3.5%）（95%置信区间[CI] = - 17:01, - 8:36）。我们发现，晚上工作对夜班工人有很强的保护作用：PGS每增加一个标准差，夜班工作的睡眠时间就会减少4分钟（28%）（CI = 0:10, 7:04）。这种保护作用对那些工作时间最长的人尤为明显。一致的模式被观察到与活动仪衍生的睡眠持续时间的测量。这些发现表明，夜班工作对健康的影响的解决方案应该考虑到个体的睡眠类型差异。
Previous research has linked having an eveningness chronotype with a higher tolerance for night shift work, suggesting the ability to work nights without health consequences may partially depend upon having a circadian clock optimized for these times. As chronotypes entrain over time to environmental cues, it remains unclear whether higher relative eveningness among healthy night workers reflects a moderating or mediating effect of chronotype on health. We address these concerns conducting a genome-wide association study and utilizing a polygenic score (PGS) for eveningness as a time-invariant measure of chronotype. On a sample of 53 211 workers in the UK Biobank (2006–2018), we focus on the effects of night shift work on sleep duration, a channel through which night shift work adversely affects health. We ask whether a higher predisposition toward eveningness promotes night shift work tolerance. Results indicate that regular night shift work is associated with a 13-minute (3.5%) reduction in self-reported sleep per night relative to those who never work these hours (95% confidence interval [CI] = −17:01, −8:36). We find that eveningness has a strong protective effect on night workers: a one-SD increase in the PGS is associated with a 4-minute (28%) reduction in the night shift work sleep penalty per night (CI = 0:10, 7:04). This protective effect is pronounced for those working the longest hours. Consistent patterns are observed with an actigraphy-derived measure of sleep duration. These findings indicate that solutions to health consequences of night shift work should take individual differences in chronotype into account.
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影响因子：
5.5
作者：
Gu F;Han J;Laden F;Pan A;Caporaso NE;Stampfer MJ;Kawachi I;Rexrode KM;Willett WC;Hankinson SE;Speizer FE;Schernhammer ES
通讯作者：
Schernhammer ES
护士的转移工作：表型和基因型对适应的贡献。
影响因子：
3.7
作者：
Gamble KL;Motsinger-Reif AA;Hida A;Borsetti HM;Servick SV;Ciarleglio CM;Robbins S;Hicks J;Carver K;Hamilton N;Wells N;Summar ML;McMahon DG;Johnson CH
通讯作者：
Johnson CH
影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
30.8
作者：
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者：
Neale, Benjamin M.
DOI：
10.1093/bioinformatics/btu848
发表时间：
2015-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Euesden J;Lewis CM;O'Reilly PF
通讯作者：
O'Reilly PF