Shift work in nurses: contribution of phenotypes and genotypes to adaptation.
Shift work in nurses: contribution of phenotypes and genotypes to adaptation.
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护士的转移工作：表型和基因型对适应的贡献。
DOI：
10.1371/journal.pone.0018395
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发表时间：
2011-04-13
期刊：
影响因子：
3.7
通讯作者：
Johnson CH
中科院分区：
文献类型：
--
作者：
Gamble KL;Motsinger-Reif AA;Hida A;Borsetti HM;Servick SV;Ciarleglio CM;Robbins S;Hicks J;Carver K;Hamilton N;Wells N;Summar ML;McMahon DG;Johnson CH
每日睡眠/觉醒周期、激素和生理过程往往与轮班工作期间的行为模式不一致，导致患心血管/代谢/胃肠道疾病、某些类型的癌症以及包括抑郁和焦虑在内的精神障碍的风险增加。目前尚不清楚睡眠时间、睡眠时间类型和生物钟基因变异如何影响轮班工作的适应。对 388 名医院白班和夜班护士新定义的睡眠策略、时间型和生物钟基因多态性的基因型进行了评估。以睡眠不足为手段在工作日切换白天睡眠的夜班护士（约 25%）最不适应自己的工作安排。睡眠时间型也影响适应的效果。此外，在单基因座和多基因座模型中，CLOCK、NPAS2、PER2 和 PER3 的多态性与酒精/咖啡因消耗和困倦以及睡眠阶段、惯性和持续时间等结果显着相关。其中许多结果特定于轮班类型，表明基因型和环境之间存在相互作用（在本例中为轮班工作）。睡眠策略、时间型和基因型有助于昼夜节律系统适应在不同的明暗周期和社交/工作时间安排之间频繁和/或不规则切换的环境。这项针对轮班护士的研究说明了生理和新陈代谢的时间组织的环境“压力”如何产生行为和健康相关的后果。由于护士是医疗保健的关键组成部分，这些发现可能对医疗保健政策产生重要影响。
Daily cycles of sleep/wake, hormones, and physiological processes are often misaligned with behavioral patterns during shift work, leading to an increased risk of developing cardiovascular/metabolic/gastrointestinal disorders, some types of cancer, and mental disorders including depression and anxiety. It is unclear how sleep timing, chronotype, and circadian clock gene variation contribute to adaptation to shift work. Newly defined sleep strategies, chronotype, and genotype for polymorphisms in circadian clock genes were assessed in 388 hospital day- and night-shift nurses. Night-shift nurses who used sleep deprivation as a means to switch to and from diurnal sleep on work days (∼25%) were the most poorly adapted to their work schedule. Chronotype also influenced efficacy of adaptation. In addition, polymorphisms in CLOCK, NPAS2, PER2, and PER3 were significantly associated with outcomes such as alcohol/caffeine consumption and sleepiness, as well as sleep phase, inertia and duration in both single- and multi-locus models. Many of these results were specific to shift type suggesting an interaction between genotype and environment (in this case, shift work). Sleep strategy, chronotype, and genotype contribute to the adaptation of the circadian system to an environment that switches frequently and/or irregularly between different schedules of the light-dark cycle and social/workplace time. This study of shift work nurses illustrates how an environmental “stress” to the temporal organization of physiology and metabolism can have behavioral and health-related consequences. Because nurses are a key component of health care, these findings could have important implications for health-care policy.
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影响因子：
3.7
作者：
Goel N;Banks S;Mignot E;Dinges DF
通讯作者：
Dinges DF
影响因子：
3.5
作者：
Carpen, Jayshan D.;von Schantz, Malcolm;Archer, Simon N.
通讯作者：
Archer, Simon N.
影响因子：
5.1
作者：
Burch, James B.;Tom, Jasmine;Ogoussan, Kisito
通讯作者：
Ogoussan, Kisito
影响因子：
3.5
作者：
Ciarleglio CM;Ryckman KK;Servick SV;Hida A;Robbins S;Wells N;Hicks J;Larson SA;Wiedermann JP;Carver K;Hamilton N;Kidd KK;Kidd JR;Smith JR;Friedlaender J;McMahon DG;Williams SM;Summar ML;Johnson CH
通讯作者：
Johnson CH
影响因子：
--
作者：
Englund A;Kovanen L;Saarikoski ST;Haukka J;Reunanen A;Aromaa A;Lönnqvist J;Partonen T
通讯作者：
Partonen T