Mucosal HIV transmission and vaccination strategies through oral compared with vaginal and rectal routes.
Mucosal HIV transmission and vaccination strategies through oral compared with vaginal and rectal routes.
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DOI：
10.1517/14712598.2010.496776
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发表时间：
2010-08
影响因子：
4.6
通讯作者：
Vajdy M
中科院分区：
文献类型：
--
作者：
Yu M;Vajdy M
目前有超过3000万人感染艾滋病毒，没有疫苗可用于预防艾滋病毒感染或疾病。泌尿生殖道、直肠和口腔粘膜是HIV的粘膜传播途径。一种能诱导全身和局部粘膜免疫的有效疫苗被普遍认为是预防粘膜HIV传播和AIDS的主要手段。结构和细胞，包括口腔，阴道和直肠粘膜有关的艾滋病毒传播和疫苗接种策略，通过每一个粘膜途径，以防止粘膜和全身感染将进行讨论。涵盖20世纪80年代至2010年的出版物，HIV的粘膜传播以及当前和以前的疫苗接种方法进行了讨论。虽然艾滋病毒的口腔传播远不如阴道和直肠传播常见，但通过这一途径的感染确实通过口交以及母婴垂直传播发生。针对口腔和其他粘膜HIV传播的粘膜疫苗接种策略正在进行深入研究，但缺乏对保护的免疫相关性的共识，缺乏安全有效的粘膜佐剂和递送系统，阻碍了获得许可的疫苗的进展。
There are currently over thirty million people infected with HIV and there are no vaccines available to prevent HIV infections or disease. The genitourinary, rectal and oral mucosa are the mucosal HIV transmission routes. An effective vaccine that can induce both systemic and local mucosal immunity is generally accepted as a major means of protection against mucosal HIV transmission and AIDS. Structure and cells that comprise the oral, vaginal and rectal mucosa pertaining to HIV transmission and vaccination strategies through each mucosal route to prevent mucosal and systemic infection will be discussed. Covering publications from 1980’s through 2010, mucosal transmission of HIV and current and previous approaches to vaccinations are discussed. Although oral transmission of HIV is far less common than vaginal and rectal transmissions, infections through this route do occur through oral sex as well as vertically from mother to child. Mucosal vaccination strategies against oral and other mucosal HIV transmissions are under intense research but the lack of consensus on immune correlates of protection and lack of safe and effective mucosal adjuvants and delivery systems hamper progress towards a licensed vaccine.
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影响因子：
3.1
作者：
Bergquist, C;Johansson, EL;Rudin, A
通讯作者：
Rudin, A
影响因子：
4.3
作者：
BJERCKE, S;SCOTT, H;THORSBY, E
通讯作者：
THORSBY, E
影响因子：
3.8
作者：
Challacombe, SJ;Sweet, SP
通讯作者：
Sweet, SP
DOI：
10.1111/j.1471-0528.1985.tb03080.x
发表时间：
1985-01-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
EDWARDS, JNT;MORRIS, HB
通讯作者：
MORRIS, HB
影响因子：
4.4
作者：
Devito, C;Zuber, B;Hinkula, J
通讯作者：
Hinkula, J