Methodology for combined TMS and EEG.

Methodology for combined TMS and EEG.
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联合TMS和EEG的方法。

DOI:
10.1007/s10548-009-0123-4
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发表时间:
2010-01
期刊:
影响因子:
2.7
通讯作者:
Kicic, Dubravko
Kicic, Dubravko
中科院分区:
医学3区
文献类型:
--
作者:
Ilmoniemi, Risto J.;Kicic, Dubravko

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经颅磁刺激(TMS)与同步脑电图(EEG)的结合为我们提供了无创探测大脑兴奋性、时间分辨连接性和瞬时状态的可能性。早期尝试将联合收割机TMS和EEG相结合,由于刺激脉冲引起的电场,EEG中出现了巨大的电磁伪影。为了解决这个问题,TMS兼容的EEG系统已经被开发出来。然而,即使放大器对脉冲免疫或快速恢复,仍然存在巨大的挑战。伪影可能来自电极的移动、来自由脉冲激活的肌肉、来自眼睛运动、来自电极极化或来自由线圈点击引起的大脑反应。通过谨慎的预防措施,这些问题中的许多都可以避免。剩余的伪影通常可以通过滤波来减少,但通常需要控制实验来确保测量的信号实际上起源于大脑。几项研究表明,TMS-EEG的强大功能为我们提供了有关大脑兴奋性或连通性的宝贵信息。
The combination of transcranial magnetic stimulation (TMS) with simultaneous electroencephalography (EEG) provides us the possibility to non-invasively probe the brain’s excitability, time-resolved connectivity and instantaneous state. Early attempts to combine TMS and EEG suffered from the huge electromagnetic artifacts seen in EEG as a result of the electric field induced by the stimulus pulses. To deal with this problem, TMS-compatible EEG systems have been developed. However, even with amplifiers that are either immune to or recover quickly from the pulse, great challenges remain. Artifacts may arise from the movement of electrodes, from muscles activated by the pulse, from eye movements, from electrode polarization, or from brain responses evoked by the coil click. With careful precautions, many of these problems can be avoided. The remaining artifacts can be usually reduced by filtering, but control experiments are often needed to make sure that the measured signals actually originate in the brain. Several studies have shown the power of TMS–EEG by giving us valuable information about the excitability or connectivity of the brain.
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