Racial differences in glycemic markers: a cross-sectional analysis of community-based data.
Racial differences in glycemic markers: a cross-sectional analysis of community-based data.
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DOI：
10.7326/0003-4819-154-5-201103010-00004
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发表时间：
2011-03-01
影响因子：
39.2
通讯作者：
Brancati FL
中科院分区：
文献类型：
--
作者：
Selvin E;Steffes MW;Ballantyne CM;Hoogeveen RC;Coresh J;Brancati FL
虽然黑人和白色人血红蛋白A1 c（HbA 1 c）值的差异已经得到了很好的证实，但最近的研究表明，这种差异可能并不反映出HbA 1 c的差异。研究血糖标志物的种族差异，包括那些反映独立于血红蛋白糖化和红细胞转换的生物学过程的标志物。横截面。以社区为基础。1376名非糖尿病和343名糖尿病成人参与社区动脉粥样硬化风险研究的子研究。血红蛋白A1 c、空腹血糖、糖化白蛋白、果糖胺和1，5-脱水葡萄糖醇水平。在糖尿病患者和非糖尿病患者中，调整协变量和空腹血糖浓度前后，黑人的HbA 1c、糖化白蛋白和果糖胺水平均显著高于白色人。血清1，5-脱水葡萄糖醇，这是减少设置高血糖症引起的糖尿，是较低的黑人与白色人相比，虽然这种差异是统计学上的显着性只有在非糖尿病成人。该研究采用横断面设计，纳入了有限数量的有糖尿病史的受试者，并且该研究不包括循环非空腹糖化白蛋白、果糖胺和1，5-脱水葡萄糖醇的黑人和白色差异以及HbA 1c值的黑人和白色差异的综合测量。血红蛋白糖化和红细胞更新的种族差异不能解释这些血清标志物的种族差异。黑人有系统性的更高水平的非空腹血糖的可能性值得进一步研究。
Although black and white differences in hemoglobin A1c (HbA1c) values are well established, recent studies suggest that the difference might not reflect differences in glycemia. To investigate racial disparities in glycemic markers, including those that reflect biological processes independent of hemoglobin glycation and erythrocyte turnover. Cross-sectional. Community-based. 1376 nondiabetic and 343 diabetic adults in a substudy of the Atherosclerosis Risk in Communities Study. Hemoglobin A1c, fasting glucose, glycated albumin, fructosamine, and 1,5-anhydroglucitol levels. In persons with and without diabetes, black persons had significantly higher values of HbA1c, glycated albumin, and fructosamine levels compared with white persons before and after adjustment for covariates and fasting glucose concentration. Serum 1,5-anhydroglucitol, which is reduced in the setting of hyperglycemia-induced glycosuria, was lower in black persons compared with white persons, although this difference was statistically significant only in nondiabetic adults. The design was cross-sectional, a limited number of participants with a history of diabetes were included, and the study did not include integrated measures of circulating nonfasting glycemia Black and white differences in glycated albumin, fructosamine, and 1,5-anhydroglucitol parallel black and white differences in HbA1c values. Racial differences in hemoglobin glycation and erythrocyte turnover cannot explain racial disparities in these serum markers. The possibility that black persons have systematically higher levels of nonfasting glycemia deserves further study.
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影响因子：
7.7
作者：
Borg R;Kuenen JC;Carstensen B;Zheng H;Nathan DM;Heine RJ;Nerup J;Borch-Johnsen K;Witte DR;ADAG Study Group
通讯作者：
ADAG Study Group
影响因子：
16.2
作者：
Pal A;Farmer AJ;Dudley C;Selwood MP;Barrow BA;Klyne R;Grew JP;McCarthy MI;Gloyn AL;Owen KR
通讯作者：
Owen KR
影响因子：
16.2
作者：
通讯作者：
--
影响因子：
7.7
作者：
Selvin, Elizabeth;Ning, Yang;Coresh, Josef
通讯作者：
Coresh, Josef
影响因子：
5
作者：
Eldeirawi, K;Lipton, RB
通讯作者：
Lipton, RB