Association between hemoglobin A1c and carotid atherosclerosis in rural community-dwelling elderly Japanese men.
Association between hemoglobin A1c and carotid atherosclerosis in rural community-dwelling elderly Japanese men.
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DOI：
10.1186/s40101-015-0054-6
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发表时间：
2015-04-01
影响因子：
3.1
通讯作者：
Maeda T
中科院分区：
文献类型：
--
作者：
Shimizu Y;Nakazato M;Sato S;Koyamatsu J;Yamanashi H;Nagayoshi M;Kadota K;Hayashida N;Yamasaki H;Kusano Y;Takamura N;Aoyagi K;Maeda T
最近的研究报告了较高和较低水平的血红蛋白A1 c（HbA 1c）与糖尿病患者较高的死亡率之间的关联。与糖尿病一样，颈动脉粥样硬化是一种众所周知的生活方式相关疾病。然而，还没有研究报告HbA 1c水平和颈动脉粥样硬化之间的关联。我们对1，150名正在接受一般健康检查的年龄≥60岁的日本老年男性进行了一项横断面研究。颈动脉粥样硬化定义为颈动脉内膜中层厚度（CIMT）≥1.1 mm。由于体重指数（BMI）被认为是一个心血管危险因素，对HbA 1c水平和颈动脉粥样硬化有很大的影响，我们根据BMI对这种风险进行了分层分析。使用中等HbA 1c五分位数作为参考组，HbA 1c最低五分位数组显示低BMI（≤23 kg/m2）患者的颈动脉粥样硬化风险显著高于高BMI（>23 kg/m2）患者。当这些分析仅限于未服用降糖药物或高脂血症和心血管疾病药物的受试者时，HbA 1c与颈动脉粥样硬化的相关性略强。校正经典心血管危险因素后，颈动脉粥样硬化的校正比值比（OR）为1.36（0.84至2.20）的总受试者，2.29（1.12至4.66）的低BMI组，0.68（0.33至1.41）的高BMI组。低HbA 1c水平是低BMI但不高BMI的日本农村社区老年男性颈动脉粥样硬化的一个重要危险因素，特别是在那些未服用降糖药物的人群中。
Recent studies have reported an association between both higher and lower levels of hemoglobin A1c (HbA1c) and higher mortality of diabetes patients. Like diabetes, carotid atherosclerosis is a well known lifestyle-related disease. However, no studies have yet reported an association between HbA1c levels and carotid atherosclerosis. We conducted a cross-sectional study of 1,150 Japanese elderly men aged ≥60 years who were undergoing general health checkups. Carotid atherosclerosis was defined as a carotid intima-media thickness (CIMT) ≥1.1 mm. Since body mass index (BMI) is regarded as a cardiovascular risk factor that exerts a strong influence on both HbA1c levels and carotid atherosclerosis, we performed a stratified analysis of this risk based on BMI. Using the intermediate HbA1c quintile as a reference group, the groups in the lowest HbA1c quintiles showed a significantly higher risk of carotid atherosclerosis in patients with low BMI (≤23 kg/m2) vs. no increased risk in those with high BMI (>23 kg/m2). The association of HbA1c with carotid atherosclerosis became slightly stronger when these analyses were limited to subjects who were not taking glucose-lowering medications or medications for hyperlipidemia and cardiovascular disease. After adjusting for classical cardiovascular risk factors, adjusted odds ratios (ORs) for carotid atherosclerosis were 1.36 (0.84 to 2.20) for total subjects, 2.29 (1.12 to 4.66) for low-BMI groups, and 0.68 (0.33 to 1.41) for high-BMI groups. Lower HbA1c level is a significant risk factor for carotid atherosclerosis in rural community-dwelling elderly Japanese men with low, but not high BMI, particularly in those not taking glucose-lowering medication.
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影响因子：
8.3
作者：
Kiechl, S;Willeit, J;Bonora, E
通讯作者：
Bonora, E
影响因子：
8.3
作者：
Myint, Phyo K.;Sinha, Shubhada;Khaw, Kay-Tee
通讯作者：
Khaw, Kay-Tee
DOI：
10.2215/cjn.00800209
发表时间：
2009-06-01
影响因子：
9.8
作者：
Moen, Maureen F.;Zhan, Min;Fink, Jeffrey C.
通讯作者：
Fink, Jeffrey C.
影响因子：
5.9
作者：
Huang, ES;Meigs, JB;Singer, DE
通讯作者：
Singer, DE
影响因子：
3.2
作者：
Yanase, Toshihiko;Nasu, Shigeru;Nawata, Hajime
通讯作者：
Nawata, Hajime