SARS-CoV-2 Viral Load on Admission Is Associated With 30-Day Mortality.

SARS-CoV-2 Viral Load on Admission Is Associated With 30-Day Mortality.
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DOI:
10.1093/ofid/ofaa535
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发表时间:
2020-12
影响因子:
4.2
通讯作者:
Greninger AL
Greninger AL
中科院分区:
医学3区
文献类型:
--
作者:
Bryan A;Fink SL;Gattuso MA;Pepper G;Chaudhary A;Wener MH;Morishima C;Jerome KR;Mathias PC;Greninger AL

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入院时严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 病毒载量与 30 天死亡率显着增加相关(比值比 [OR],4.20;95% CI,1.62–10.86),入院时抗 SARS-CoV-2 核衣壳蛋白 IgG 血清阳性有降低 30 天死亡率的趋势(OR,0.43;95% CI, 0.15–1.26)。定量 SARS-CoV-2 病毒载量和血清学检测的报告可以提供预后临床信息。对来自一家社区医院的 181 名患者进行的一项研究发现,入院时 SARS-CoV-2 病毒载量与 30 天死亡率显着增加相关(OR 4.20 [95% CI:1.62-10.86]),入院时抗 SARS-CoV-2 IgG 血清阳性有降低 30 天死亡率的趋势(OR 0.43 [95% CI:0.15-1.26])。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load on admission was associated with a significantly increased 30-day mortality (odds ratio [OR], 4.20; 95% CI, 1.62–10.86), and anti-SARS-CoV-2 nucleocapisid IgG seropositivity on admission trended toward a reduced 30-day mortality (OR, 0.43; 95% CI, 0.15–1.26). Reporting of quantitative SARS-CoV-2 viral load and serologic assays may offer prognostic clinical information. A study of 181 individuals from a single community hospital found SARS-CoV-2 viral load on admission was associated with a significantly increased 30-day mortality (OR 4.20 [95% CI: 1.62-10.86]), and anti-SARS-CoV-2 IgG seropositivity on admission trended toward a reduced 30-day mortality (OR 0.43 [95% CI: 0.15-1.26]).
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