Longitudinal changes in telomere length and associated genetic parameters in dairy cattle analysed using random regression models.
Longitudinal changes in telomere length and associated genetic parameters in dairy cattle analysed using random regression models.
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DOI：
10.1371/journal.pone.0192864
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Banos G
中科院分区：
文献类型：
--
作者：
Seeker LA;Ilska JJ;Psifidi A;Wilbourn RV;Underwood SL;Fairlie J;Holland R;Froy H;Bagnall A;Whitelaw B;Coffey M;Nussey DH;Banos G
在许多生物体中，端粒覆盖在线性染色体的末端，并随着年龄的增长而缩短。在人类中，短端粒与发病率和死亡率有关。随着纵向数据集的积累，焦点从研究端粒长度（TL）转移到探索TL随时间的变化。一些研究表明，端粒磨损的速度是未来疾病的预测。本研究的目的是1）表征牛相对白细胞TL（RLTL）在荷斯坦黑白花奶牛一生中的变化，2）估计RLTL随时间的遗传参数，3）调查个体RLTL谱的差异与生产寿命的关联。RLTL测量进行了分析，使用勒让德多项式在一个随机回归模型来描述TL配置文件和遗传方差随年龄的变化。分析基于308头雌性荷斯坦黑白花奶牛的1，328次重复RLTL测量。将二次勒让德多项式拟合至月龄的固定效应和动物身份的随机效应。计算并说明了QTL、遗传力和性状内遗传相关沿着年龄轨迹的变化。在群体水平上，RLTL与年龄的关系可用正二次函数描述。个体在一生中RLTL变化的方向和数量方面差异显着。RLTL的遗传力范围为0.36 - 0.47（SE = 0.05 - 0.08），随时间的推移保持统计学不变。RLTL在出生时的测量在生活后期的遗传相关性下降的采样之间的时间间隔从近1至0.69，表明TL在生活后期可能是由不同的基因比TL在生活早期。尽管动物的RLTL谱存在显著差异，但这些差异与生产寿命无关（p = 0.954）。
Telomeres cap the ends of linear chromosomes and shorten with age in many organisms. In humans short telomeres have been linked to morbidity and mortality. With the accumulation of longitudinal datasets the focus shifts from investigating telomere length (TL) to exploring TL change within individuals over time. Some studies indicate that the speed of telomere attrition is predictive of future disease. The objectives of the present study were to 1) characterize the change in bovine relative leukocyte TL (RLTL) across the lifetime in Holstein Friesian dairy cattle, 2) estimate genetic parameters of RLTL over time and 3) investigate the association of differences in individual RLTL profiles with productive lifespan. RLTL measurements were analysed using Legendre polynomials in a random regression model to describe TL profiles and genetic variance over age. The analyses were based on 1,328 repeated RLTL measurements of 308 female Holstein Friesian dairy cattle. A quadratic Legendre polynomial was fitted to the fixed effect of age in months and to the random effect of the animal identity. Changes in RLTL, heritability and within-trait genetic correlation along the age trajectory were calculated and illustrated. At a population level, the relationship between RLTL and age was described by a positive quadratic function. Individuals varied significantly regarding the direction and amount of RLTL change over life. The heritability of RLTL ranged from 0.36 to 0.47 (SE = 0.05–0.08) and remained statistically unchanged over time. The genetic correlation of RLTL at birth with measurements later in life decreased with the time interval between samplings from near unity to 0.69, indicating that TL later in life might be regulated by different genes than TL early in life. Even though animals differed in their RLTL profiles significantly, those differences were not correlated with productive lifespan (p = 0.954).
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DOI：
10.1098/rspb.2004.2768
发表时间：
2004-08-07
影响因子：
4.7
作者：
Hall, ME;Nasir, L;Monaghan, P
通讯作者：
Monaghan, P
影响因子：
2.3
作者：
Arnold, Todd W.
通讯作者：
Arnold, Todd W.
影响因子：
7.8
作者：
Bakaysa, Stephanie L.;Mucci, Lorelei A.;Pedersen, Nancy L.
通讯作者：
Pedersen, Nancy L.
影响因子：
3.7
作者：
Farzaneh-Far R;Desir GV;Na B;Schiller NB;Whooley MA
通讯作者：
Whooley MA
影响因子：
3.3
作者：
Englishby, T. M.;Banos, G.;Berry, D. P.
通讯作者：
Berry, D. P.