Commentary: Sca-1 and Cells of the Lung: A matter of Different Sorts.
Commentary: Sca-1 and Cells of the Lung: A matter of Different Sorts.
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DOI：
10.1002/stem.10
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发表时间：
2009-03
期刊：
影响因子：
5.2
通讯作者：
Kim, Carla F.
中科院分区：
文献类型：
--
作者：
Raiser, David M.;Kim, Carla F.
Teisanu 等人在本期发表的两篇独立论文中。和麦奎尔特等人。报告使用流式细胞术和细胞分选来鉴定细胞表面标记物 Sca-1 表达低但 CD34 阴性的假定细支气管干细胞，以及来自肺部的 Sca-1 阳性间充质成纤维祖细胞群。乍一看，这些研究似乎表明 Sca-1 和 CD34 并不是肺部上皮干细胞群的标志物，正如我们之前在鉴定支气管肺泡干细胞 (BASC) 的研究中所确定的那样，并且也可能似乎彼此矛盾。然而，在这里我们指出的证据表明，这三项研究的结果并不相互排斥，相反，这些研究中使用的不同细胞分离和培养方案允许识别独特的肺细胞群。这些研究并没有贬低之前关于 BASC 的工作，而是揭示了新方法和新细胞类型的存在，由于它们在肺生物学和肺疾病中的重要性，它们在未来的功能测试中将很有趣。
In two separate papers published in this issue, Teisanu et al. and McQualter et al. report the use of flow cytometry and cell sorting to identify putative bronchiolar stem cells that are low in expression for the cell surface marker Sca-1 yet negative for CD34, and a mesenchymal, fibroblastic progenitor cell population from the lung that is positive for Sca-1, respectively. At first glance, these studies may seem to suggest that Sca-1 and CD34 are not markers of an epithelial stem cell population in the lung, as we previously determined in studies that identified bronchioalveolar stem cells (BASCs), and may also appear to contradict each other. However, here we point to evidence that the findings of these three studies are not mutually exclusive, and rather, that the different cell isolation and culturing protocols used in these studies have allowed for the identification of unique pulmonary cell populations. Rather than discounting previous work on BASCs, these studies reveal the existence of new methods and new cell types which will be interesting to use in future functional tests for their importance in lung biology and lung disease.
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