Amino acid biosynthesis deficiency in bacteria associated with human and animal hosts.
Amino acid biosynthesis deficiency in bacteria associated with human and animal hosts.
复制标题
DOI：
10.1016/j.meegid.2009.02.002
复制
发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Yu XJ;Walker DH;Liu Y;Zhang L
机会致病菌持续生活在人体内，专性致病菌只有在疾病的情况下才与人联系。一个谜是病原体是否能在宿主外生存。我们在这里展示了大多数人类病原体已经失去了氨基酸的生物合成途径。这种情况表明，大多数微生物病原体是专性依赖宿主的，它们不能在宿主外繁殖。进一步的基因组大小分析显示，依赖宿主的细菌的基因组比自由活细菌的基因组小，这表明基因组的还原性进化广泛发生在与人类和动物宿主密切相关的细菌病原体和非病原体中。基因组减少的程度似乎取决于它们所处的环境。环境中的营养物质越丰富，细菌中的基因组就越小。
Opportunistic pathogenic bacteria continuously live in humans and obligately pathogenic bacteria associate with humans only in the case of diseases. A mystery is whether pathogens can live outside the hosts. We showed here that most human pathogens have lost biosynthetic pathways for amino acids. This condition suggests that most microbial pathogens are obligately host-dependent and they cannot multiply outside their hosts. Further analysis of the genome sizes revealed that the genomes of host-dependent bacteria are smaller than those of free living bacteria, suggesting that reductive evolution of genomes occurs broadly in bacterial pathogens and non-pathogens closely associated with human and animal hosts. The extent of genome reduction appears to depend on the environment in which they reside. The richer the nutrients are in the environment the smaller the genome is in the bacteria.
登录
查看更多内容
影响因子：
3.1
作者：
Chain, PSG;Comerci, DJ;Garcia, E
通讯作者：
Garcia, E
影响因子：
2.1
作者：
Kim, S;Kurokawa, D;Watarai, M
通讯作者：
Watarai, M
影响因子：
4.4
作者：
Amaro, C;Biosca, EG
通讯作者：
Biosca, EG
影响因子：
3.4
作者：
Zhang, Jian-zhi;Popov, Vsevolod L.;Yu, Xue-jie
通讯作者：
Yu, Xue-jie
影响因子：
9.4
作者：
WELLS, JG;SHIPMAN, LD;WACHSMUTH, IK
通讯作者：
WACHSMUTH, IK