Circulating levels of cardiac troponin T are associated with coronary noncalcified plaque burden in HIV-infected adults: a pilot study.
Circulating levels of cardiac troponin T are associated with coronary noncalcified plaque burden in HIV-infected adults: a pilot study.
复制标题
DOI：
10.1177/0956462418800873
复制
发表时间：
2019-03
影响因子：
1.4
通讯作者：
Lai S
中科院分区：
文献类型：
--
作者：
Foster P;Sokoll L;Li J;Gerstenblith G;Fishman EK;Kickler T;Chen S;Tai H;Lai H;Lai S
HIV感染和/或抗逆转录病毒治疗可能增加亚临床冠状动脉粥样硬化的风险。然而，慢性肾脏疾病（CKD）患者和没有静脉通道的患者不能进行冠脉CT血管造影（CCTA）。本研究旨在通过CCTA评估HIV感染者心肌肌钙蛋白T （cTnT）水平与冠状动脉斑块负荷程度之间的关系。在2017年6月至9月期间，招募了58名感染艾滋病毒的参与者并接受了对比增强的CCTA。使用Elecsys肌钙蛋白T Gen 5 STAT法测量cTnT，使用冠状动脉斑块分析量化非钙化斑块负荷。采用稳健回归模型进行初步统计分析。单因素稳健回归分析显示，男性、2013年ACC/AHA心血管风险评分算法定义的心血管风险评分和cTnT水平与非钙化斑块体积指数（NCPI）显著相关。最终的稳健回归分析显示，只有cTnT（对数尺度）与NCPI独立相关（回归系数：0.0453,95% CI: 0.0151, 0.0755, p = 0.003）。这些研究结果表明，cTnT可能是冠状动脉斑块负荷的一个有希望的标志物，特别是在hiv相关CKD患者或没有静脉注射的患者中。
HIV infection and/or antiretroviral therapy may increase the risk of subclinical coronary atherosclerosis. However, patients with chronic kidney disease (CKD) and those without IV access cannot undergo contrast-enhanced coronary CT angiography (CCTA). This study was to explore the relationship between cardiac troponin T (cTnT) levels and the extent of coronary plaque burden, as assessed by CCTA in those with HIV infection. Between June and September 2017, 58 HIV-infected participants were recruited and underwent contrast-enhanced CCTA. cTnT was measured with the Elecsys Troponin T Gen 5 STAT assay, and noncalcified plaque burden was quantified using coronary plaque analysis. Robust regression model was employed to perform primary statistical analysis. Univariate robust regression analysis indicated that male gender, cardiovascular risk score defined by the 2013 ACC/AHA cardiovascular risk score algorithm, and cTnT levels were significantly associated with noncalcified plaque volume index (NCPI). Final robust regression analyses showed that only cTnT (log scale) was independently associated with the NCPI (regression coefficient: 0.0453 with 95% CI: 0.0151, 0.0755, p = 0.003). These results of this study suggest that cTnT may be a promising marker for coronary plaque burden, especially in patients with HIV-associated CKD or without IV access.
登录
查看更多内容
影响因子：
5.7
作者：
Korosoglou, Grigorios;Lehrke, Stephanie;Katus, Hugo A.
通讯作者：
Katus, Hugo A.
影响因子：
5.3
作者：
Auscher, Soren;Heinsen, Laurits;Egstrup, Kenneth
通讯作者：
Egstrup, Kenneth
影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
影响因子：
4.9
作者：
Lai, SH;Lai, H;Bartlett, JG
通讯作者：
Bartlett, JG
DOI：
10.1097/01.qai.0000017995.56638.f8
发表时间：
2002-07-01
期刊：
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
影响因子：
--
作者：
Meng, QY;Lima, JAC;Lai, SH
通讯作者：
Lai, SH