Depression is an early disease manifestation in lupus-prone MRL/lpr mice.
Depression is an early disease manifestation in lupus-prone MRL/lpr mice.
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DOI：
10.1016/j.jneuroim.2008.11.009
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发表时间：
2009-02-15
影响因子：
3.3
通讯作者：
Putterman C
中科院分区：
文献类型：
--
作者：
Gao HX;Campbell SR;Cui MH;Zong P;Hee-Hwang J;Gulinello M;Putterman C
许多狼疮患者出现神经精神表现，包括认知功能障碍、抑郁和焦虑。然而，尚不清楚神经精神性狼疮是原发性疾病表现，还是继发于非中枢神经系统疾病。我们发现，MRL/lpr狼疮易感小鼠在8周龄时已经表现出明显的抑郁样行为，尽管它们的视觉工作记忆、运动协调和社会偏好正常。此外，抑郁症与抗DNA、NMDA受体和心磷脂的自身抗体滴度显著相关。我们的研究结果表明，狼疮小鼠在疾病过程中很早就出现抑郁和中枢神经系统功能障碍，没有涉及其他靶器官的实质性病理。
Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs.
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影响因子：
8.3
作者：
Brey, RL;Abbott, RD;Kittner, SJ
通讯作者：
Kittner, SJ
影响因子：
5.2
作者：
Hermosillo-Romo, D;Brey, RL
通讯作者：
Brey, RL
影响因子：
4.4
作者：
Miyasaka, Naoyuki;Takahashi, Kan;Hetherington, Hoby P.
通讯作者：
Hetherington, Hoby P.
DOI：
10.1073/pnas.0608397104
发表时间：
2006-12-26
影响因子：
11.1
作者：
Kowal, Czeslawa;DeGiorgio, Lorraine A.;Diamond, Betty
通讯作者：
Diamond, Betty
影响因子：
2.2
作者：
Garwood, M;DelaBarre, L
通讯作者：
DelaBarre, L