A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population.
A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population.
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DOI：
10.1186/s12876-015-0286-2
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发表时间：
2015-05-12
影响因子：
2.4
通讯作者：
Xu J
中科院分区：
文献类型：
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作者：
Chen J;Wang W;Li X;Xu J
针对IL28BB中两个SNPs(rs12979860和rs8099917)的小样本量相关性研究结果不一致，本研究旨在通过Meta分析评价这两个SNPs与亚洲人群，特别是中国人群中乙肝病毒感染易感性的关系。检索相关文献，用STATA11.0软件对亚洲人群和中国人群的IL28B(rs12979860和rs8099917)分别进行Meta分析。在亚洲人群和中国人群分析中，rs12979860的合并优势比(OR)分别为0.79(95%CI，0.53~1.18；P = 0.25，I2 = 63.2%)和1.62(95%CI，1.0 4~2.51；P = 0.033，I2 = 54.3%)。在亚洲人群和中国人群分析中，rs8099917的合并OR值分别为1.0 5(95%CI，0.93~1.19；P = 0.44，I2 = 43.3%)和0.97(95%CI，0.84~1.2 3；P = 0.726，I 2 = 15.6%)。我们的研究表明，在加性遗传模型下，rs12979680的T等位基因可以增加中国人感染乙肝病毒的风险，但不会增加亚洲人的感染风险。在中国人群和亚洲人群中，rs8099917与乙肝病毒感染无关。
Several association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and infection susceptibility of Hepatitis B Virus (HBV) in Asian population, especially in Chinese population by meta-analysis. Search the relevant published papers and perform meta-analysis respectively on IL28B (rs12979860 and rs8099917) in Asian population and Chinese population under an additive genetic model by STATA11.0. The pooled odds ratios (OR) of rs12979860 are 0.79 (95% CI, 0.53-1.18; P = 0.25, I2 = 63.2%) and 1.62 (95% CI, 1.04-2.51; P = 0.033, I2 = 54.3%) respectively in Asian population and Chinese population analysis. The pooled OR of rs8099917 are 1.05 (95% CI, 0.93-1.19; P = 0.44, I2 = 43.3%) and 0.97 (95% CI, 0.84-1.23; P = 0.726, I2 = 15.6%) respectively in Asian population and Chinese population analysis. Our study demonstrated that T allele of rs12979680 can increase the risk of HBV infection in Chinese population but not Asian population under an additive genetic model. There is no association between rs8099917 and HBV infection in Chinese population and Asian population.
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影响因子：
3.7
作者：
Chen J;Wang L;Li Y;Cai B;Fu Y;Liao Y;Zhang J
通讯作者：
Zhang J
中国汉族人群白细胞介素28B与乙型肝炎病毒感染的表达及基因多态性
影响因子：
6.7
作者：
Li, Wanyu;Jiang, Yanfang;Niu, Junqi
通讯作者：
Niu, Junqi
影响因子：
2
作者：
Higgins, JPT;Thompson, SG
通讯作者：
Thompson, SG
影响因子：
2.3
作者：
Tang S;Yue M;Wang J;Zhang Y;Yu R;Su J;Peng Z;Wang J
通讯作者：
Wang J
影响因子：
64.8
作者：
通讯作者：
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