Steering cell migration using microarray amplification of natural directional persistence.
Steering cell migration using microarray amplification of natural directional persistence.
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DOI：
10.1021/la2000206
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发表时间：
2011-04-05
期刊：
影响因子：
--
通讯作者：
Ho CC
中科院分区：
文献类型：
--
作者：
Kumar G;Co CC;Ho CC
Cell locomotion plays key roles in embryonic morphogenesis, wound healing, and cancer metastasis. Here we show that intermittent control of cell shape using microarrays can be used to amplify the natural directional persistence of cells and guide their continuous migration along preset paths and directions. Key to this geometry-based, gradient-free approach for directing cell migration is the finding that cell polarization, induced by the asymmetric shape of individual microarray islands, is retained as cells traverse between islands. Altering the intracellular signals involved in lamellipodia extension (Rac1), contractility (RhoA), and cell polarity (Cdc42) alters the speed of fibroblast migration on these micropatterns, but does not affect their directional bias significantly. These results provide insights on the role of cell morphology in directional movement and the design of micropatterned materials for steering cellular traffic.
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