D-Galactose Induces Chronic Oxidative Stress and Alters Gut Microbiota in Weaned Piglets.
D-Galactose Induces Chronic Oxidative Stress and Alters Gut Microbiota in Weaned Piglets.
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D-半乳糖诱导断奶仔猪慢性氧化应激并改变肠道微生物群
DOI：
10.3389/fphys.2021.634283
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发表时间：
2021
影响因子：
4
通讯作者：
Yin Y
中科院分区：
文献类型：
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作者：
Han H;Liu Z;Yin J;Gao J;He L;Wang C;Hou R;He X;Wang G;Li T;Yin Y
氧化应激是养猪生产中普遍存在的一种应激现象，可严重损害断奶仔猪的肠道功能。本试验旨在研究不同水平D-半乳糖诱导慢性氧化应激对断奶仔猪生长性能、肠道形态和肠道菌群的影响。结果表明，添加10和20 g/kg BW的D-半乳糖可降低1 ~ 3周龄的平均日增重和平均日采食量。10 g/kg BW D-半乳糖组第2周和第3周血清MDA含量显著升高。10 g/kg BW D-半乳糖显著影响空肠和回肠GPx 1、CAT 1和MnSOD的表达。16 S rRNA序列分析结果表明，与对照组相比，10和20 g/kg BW D-半乳糖显著降低了拟青霉门、丹毒丝菌属、丹毒丝菌属和丹毒丝菌科的相对丰度，而增加了阴性菌门、月单胞菌目和韦荣氏球菌科的相对丰度。结果表明，10 g/kg BW/d D-半乳糖处理3周可诱导断奶仔猪慢性氧化应激，降低其生长性能，并改变其肠道菌群。
Oxidative stress commonly occurs in pig production, which can severely damage the intestinal function of weaned piglets. This study was conducted to investigate the effects of D-galactose with different levels used to induce chronic oxidative stress on growth performance, intestinal morphology and gut microbiota in weaned piglets. The results showed that addition of 10 and 20 g/kg BW D-galactose reduced average daily gain and average daily feed intake from the first to the third week. 10 g/kg BW D-galactose increased the concentration of serum MDA at the second and third week. 10 g/kg BW D-galactose significantly influenced the jejunal and ileal expressions of GPx1, CAT1, and MnSOD. The results of 16S rRNA sequencing showed that compared with the control, 10 and 20 g/kg BW D-galactose significantly decreased the relative abundance of Tenericutes, Erysipelotrichia, Erysipelotrichales, and Erysipelotrichaceae, while increased the relative abundance of Negativicutes, Selenomonnadales, and Veillonellaceae. The results indicated that treatment with 10 g/kg BW/day D-galactose for 3 weeks could induce chronic oxidative stress, reduce the growth performance and alter gut microbiota in weaned piglets.
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影响因子：
12.2
作者：
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通讯作者：
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影响因子：
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2.4
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作者：
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通讯作者：
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影响因子：
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作者：
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