Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
复制标题
氧化应激和炎症：多酚可以为我们做什么？
DOI：
10.1155/2016/7432797
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发表时间：
2016
影响因子：
--
通讯作者：
Rahu N
中科院分区：
文献类型：
--
作者：
Hussain T;Tan B;Yin Y;Blachier F;Tossou MC;Rahu N
氧化应激被认为是活性氧物种(ROS)的产生和保护机制消除它们之间的不平衡，这可能导致慢性炎症。氧化应激可激活多种转录因子，导致炎症途径中一些基因的差异表达。氧化应激引发的炎症是许多慢性疾病的原因。多酚已被认为是有用的辅助治疗，因为它们具有潜在的抗炎作用，与抗氧化活性相关，并抑制参与二十烷类化合物产生的酶。本文就多酚类物质的抗炎和氧化作用、多酚类物质抑制氧化应激激活的分子信号通路的机制以及多酚类物质在炎症介导的慢性疾病中的可能作用进行综述。这些数据可能有助于未来抗氧化剂疗法和新型抗炎药物的开发。
Oxidative stress is viewed as an imbalance between the production of reactive oxygen species (ROS) and their elimination by protective mechanisms, which can lead to chronic inflammation. Oxidative stress can activate a variety of transcription factors, which lead to the differential expression of some genes involved in inflammatory pathways. The inflammation triggered by oxidative stress is the cause of many chronic diseases. Polyphenols have been proposed to be useful as adjuvant therapy for their potential anti‐inflammatory effect, associated with antioxidant activity, and inhibition of enzymes involved in the production of eicosanoids. This review aims at exploring the properties of polyphenols in anti‐inflammation and oxidation and the mechanisms of polyphenols inhibiting molecular signaling pathways which are activated by oxidative stress, as well as the possible roles of polyphenols in inflammation‐mediated chronic disorders. Such data can be helpful for the development of future antioxidant therapeutics and new anti‐inflammatory drugs.
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