Immunotherapy and Gene Therapy for Oncoviruses Infections: A Review.

Immunotherapy and Gene Therapy for Oncoviruses Infections: A Review.
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DOI:
10.3390/v13050822
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发表时间:
2021-05-02
期刊:
Viruses
影响因子:
--
通讯作者:
de Paula VS
de Paula VS
中科院分区:
其他
文献类型:
--
作者:
de Almeida NAA;Ribeiro CRA;Raposo JV;de Paula VS

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免疫疗法已被证明对某些类型的由病毒引起的癌症非常有效。基因治疗涉及治疗基因的插入或修饰,以纠正导致/可能导致疾病的不适当的基因产物。这两种类型的治疗都被用作避免肿瘤病毒引起的癌症的替代方法。在这篇综述中,我们总结了免疫治疗和基因治疗的最新研究,包括溶瘤免疫治疗,免疫检查点抑制剂,基因置换,反义寡核苷酸,RNA干扰,基于CRISPR的基因编辑,转录激活因子样效应核酸酶(TALENs)和EB病毒的定制治疗,人T淋巴细胞病毒1、B型肝炎病毒、人乳头瘤病毒、丙型肝炎病毒、与卡波西肉瘤相关疱疹病毒、默克尔细胞多瘤病毒和巨细胞病毒。
Immunotherapy has been shown to be highly effective in some types of cancer caused by viruses. Gene therapy involves insertion or modification of a therapeutic gene, to correct for inappropriate gene products that cause/may cause diseases. Both these types of therapy have been used as alternative ways to avoid cancers caused by oncoviruses. In this review, we summarize recent studies on immunotherapy and gene therapy including the topics of oncolytic immunotherapy, immune checkpoint inhibitors, gene replacement, antisense oligonucleotides, RNA interference, clustered regularly interspaced short palindromic repeats Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based gene editing, transcription activator-like effector nucleases (TALENs) and custom treatment for Epstein–Barr virus, human T-lymphotropic virus 1, hepatitis B virus, human papillomavirus, hepatitis C virus, herpesvirus associated with Kaposi’s sarcoma, Merkel cell polyomavirus, and cytomegalovirus.
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