Genetic, social, and environmental risk factors in rheumatoid arthritis-associated interstitial lung disease.
Genetic, social, and environmental risk factors in rheumatoid arthritis-associated interstitial lung disease.
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DOI：
10.1016/j.semarthrit.2022.152098
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发表时间：
2022-12
影响因子：
5
通讯作者：
England, Bryant R.
中科院分区：
文献类型：
--
作者：
Wheeler, Austin M.;Baker, Joshua F.;Poole, Jill A.;Ascherman, Dana P.;Yang, Yangyuna;Kerr, Gail S.;Reimold, Andreas;Kunkel, Gary;Cannon, Grant W.;Wysham, Katherine D.;Singh, Namrata;Lazaro, Deana;Monach, Paul;Bridges, S. Louis;Mikuls, Ted R.;England, Bryant R.
在北方欧洲人群中，MUC 5 B和TOLLIP单核苷酸多态性（SNP）和吸烟与类风湿性关节炎-间质性肺病（RA-ILD）相关。我们在一个按种族和吸烟史分层的大型RA队列中评估了RA-ILD是否与这些遗传变异和HLA-DRB 1共享表位（SE）等位基因相关。在患有RA的美国退伍军人中对HLA-DRB 1 SE等位基因和MUC 5 B rs35705950和TOLLIP rs 5743890 SNP进行基因分型。通过病历审查确认ILD。在逻辑回归模型中评估ILD的遗传相关性，并在根据种族和吸烟状态定义的亚组中进行评估，通过相对过度相互作用风险（RERI）评估加性相互作用。在2，556例受试者（88%男性，77%白色）中，238例（9.3%）患有ILD。MUC 5 B变异体与ILD相关（OR 2.25 [95% CI 1.69，3.02]），而TOLLIP和HLA-DRB 1 SE与ILD无关。MUC 5 B变异在黑人/非裔美国人受试者中的发生率较低（5.8% vs. 22.6%），但与所有其他受试者（OR 2.32 [1.70，3.16]）相比，其与RA-ILD的相关性在数值上更强（OR 4.23 [1.65，10.86]）。有MUC 5 B变异体和吸烟史的患者发生ILD的几率（OR 4.18 [2.53，6.93]）在数值上高于非吸烟者（OR 2.41 [1.16，5.04]）。MUC 5 B-种族和MUC 5 B-吸烟之间的加性相互作用没有统计学意义。在这个大型RA队列中，MUC 5 B启动子变体与>2倍的RA-ILD几率相关。虽然这种变异在黑人/非洲裔美国人患者中不太常见，但其在该人群中的存在使RA-ILD的几率高出>4倍。
MUC5B and TOLLIP single nucleotide polymorphisms (SNPs) and cigarette smoking were associated with rheumatoid arthritis-interstitial lung disease (RA-ILD) in a predominantly Northern European population. We evaluated whether RA-ILD is associated with these genetic variants and HLA-DRB1 shared epitope (SE) alleles in a large RA cohort stratified by race and smoking history. HLA-DRB1 SE alleles and MUC5B rs35705950 and TOLLIP rs5743890 SNPs were genotyped in U.S. veterans with RA. ILD was validated through medical record review. Genetic associations with ILD were assessed in logistic regression models overall and in subgroups defined by race and smoking status, with additive interactions assessed by the relative excess risk of interaction (RERI). Of 2,556 participants (88% male, 77% White), 238 (9.3%) had ILD. The MUC5B variant was associated with ILD (OR 2.25 [95% CI 1.69, 3.02]), whereas TOLLIP and HLA-DRB1 SE were not. The MUC5B variant was less frequent among Black/African American participants (5.8% vs. 22.6%), though its association with RA-ILD was numerically stronger (OR 4.23 [1.65, 10.86]) compared to all other participants (OR 2.32 [1.70, 3.16]). Those with the MUC5B variant and a smoking history had numerically higher odds of ILD (OR 4.18 [2.53, 6.93]) than non-smokers (OR 2.41 [1.16, 5.04]). Additive interactions between MUC5B-race and MUC5B-smoking were not statistically significant. In this large RA cohort, the MUC5B promoter variant was associated with >2-fold higher odds of RA-ILD. While this variant is less common among Black/African American patients, its presence in this population carried >4-fold higher odds of RA-ILD.
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影响因子：
30.8
作者：
Fingerlin, Tasha E.;Murphy, Elissa;Zhang, Weiming;Peljto, Anna L.;Brown, Kevin K.;Steele, Mark P.;Loyd, James E.;Cosgrove, Gregory P.;Lynch, David;Groshong, Steve;Collard, Harold R.;Wolters, Paul J.;Bradford, Williamson Z.;Kossen, Karl;Seiwert, Scott D.;du Bois, Roland M.;Garcia, Christine Kim;Devine, Megan S.;Gudmundsson, Gunnar;Isaksson, Helgi J.;Kaminski, Naftali;Zhang, Yingze;Gibson, Kevin F.;Lancaster, Lisa H.;Cogan, Joy D.;Mason, Wendi R.;Maher, Toby M.;Molyneaux, Philip L.;Wells, Athol U.;Moffatt, Miriam F.;Selman, Moises;Pardo, Annie;Kim, Dong Soon;Crapo, James D.;Make, Barry J.;Regan, Elizabeth A.;Walek, Dinesha S.;Daniel, Jerry J.;Kamatani, Yoichiro;Zelenika, Diana;Smith, Keith;McKean, David;Pedersen, Brent S.;Talbert, Janet;Kidd, Raven N.;Markin, Cheryl R.;Beckman, Kenneth B.;Lathrop, Mark;Schwarz, Marvin I.;Schwartz, David A.
通讯作者：
Schwartz, David A.
影响因子：
4.9
作者：
Mikuls TR;Gould KA;Bynoté KK;Yu F;Levan TD;Thiele GM;Michaud KD;O'Dell JR;Reimold AM;Hooker R;Caplan L;Johnson DS;Kerr G;Richards JS;Cannon GW;Criswell LA;Noble JA;Bridges SL Jr;Hughes L;Gregersen PK
通讯作者：
Gregersen PK
DOI：
10.3899/jrheum.200863
发表时间：
2021-05
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Kronzer VL;Huang W;Dellaripa PF;Huang S;Feathers V;Lu B;Iannaccone CK;Gill RR;Hatabu H;Nishino M;Crowson CS;Davis JM 3rd;Weinblatt ME;Shadick NA;Doyle TJ;Sparks JA
通讯作者：
Sparks JA
DOI：
10.1056/nejmoa1801562
发表时间：
2018-12-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Juge PA;Lee JS;Ebstein E;Furukawa H;Dobrinskikh E;Gazal S;Kannengiesser C;Ottaviani S;Oka S;Tohma S;Tsuchiya N;Rojas-Serrano J;González-Pérez MI;Mejía M;Buendía-Roldán I;Falfán-Valencia R;Ambrocio-Ortiz E;Manali E;Papiris SA;Karageorgas T;Boumpas D;Antoniou K;van Moorsel CHM;van der Vis J;de Man YA;Grutters JC;Wang Y;Borie R;Wemeau-Stervinou L;Wallaert B;Flipo RM;Nunes H;Valeyre D;Saidenberg-Kermanac'h N;Boissier MC;Marchand-Adam S;Frazier A;Richette P;Allanore Y;Sibilia J;Dromer C;Richez C;Schaeverbeke T;Lioté H;Thabut G;Nathan N;Amselem S;Soubrier M;Cottin V;Clément A;Deane K;Walts AD;Fingerlin T;Fischer A;Ryu JH;Matteson EL;Niewold TB;Assayag D;Gross A;Wolters P;Schwarz MI;Holers M;Solomon JJ;Doyle T;Rosas IO;Blauwendraat C;Nalls MA;Debray MP;Boileau C;Crestani B;Schwartz DA;Dieudé P
通讯作者：
Dieudé P
影响因子：
4.7
作者：
England, Bryant R.;Roul, Punyasha;Mikuls, Ted R.
通讯作者：
Mikuls, Ted R.