Severity of COVID-19 in children with cancer: Report from the United Kingdom Paediatric Coronavirus Cancer Monitoring Project.
Severity of COVID-19 in children with cancer: Report from the United Kingdom Paediatric Coronavirus Cancer Monitoring Project.
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癌症儿童中 COVID-19 的严重程度：英国儿科冠状病毒癌症监测项目的报告。
DOI：
10.1038/s41416-020-01181-0
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发表时间：
2021-03
影响因子：
8.8
通讯作者：
Kearns PR
中科院分区：
文献类型：
--
作者：
Millen GC;Arnold R;Cazier JB;Curley H;Feltbower RG;Gamble A;Glaser AW;Grundy RG;Lee LYW;McCabe MG;Phillips RS;Stiller CA;Várnai C;Kearns PR
患有癌症的儿童往往免疫功能低下。虽然人们普遍认为儿童感染严重SARS-CoV-2的风险低于成人，但目前还没有关于癌症儿童风险的基于人群的全面证据。我们的目标是提供证据，证明在英国所有治疗这一人群的医院就诊的癌症儿童中，SARS-CoV-2的发病率和结果。对英国所有16岁以下被诊断患有癌症的儿童进行回顾性和前瞻性观察研究，收集来自所有为该人群提供癌症治疗的医院的数据。符合条件的患者经逆转录聚合酶链反应（RT-PCR）检测为SARS-CoV-2阳性。主要终点为住院患者的死亡、出院或COVID-19积极治疗结束。在2020年3月12日至2020年7月31日期间，确定了54例病例：15例（28%）无症状，34例（63%）轻度感染，5例（10%）中度、重度或危重感染。没有患者死亡，只有3名患者需要重症监护支持。医院鉴定的16岁以下癌症儿童中SARS-CoV-2感染的估计发生率为3%。与一般儿科人群相比，患有癌症并感染SARS-CoV-2的儿童发生严重感染的风险并未增加。这是令人放心的，并支持继续提供标准治疗。
Children with cancer are frequently immunocompromised. While children are generally thought to be at less risk of severe SARS-CoV-2 infection than adults, comprehensive population-based evidence for the risk in children with cancer is unavailable. We aimed to produce evidence of the incidence and outcomes from SARS-CoV-2 in children with cancer attending all hospitals treating this population across the UK. Retrospective and prospective observational study of all children in the UK under 16 diagnosed with cancer through data collection from all hospitals providing cancer care to this population. Eligible patients tested positive for SARS-CoV-2 on reverse transcription polymerase chain reaction (RT-PCR). The primary end-point was death, discharge or end of active care for COVID-19 for those remaining in hospital. Between 12 March 2020 and 31 July 2020, 54 cases were identified: 15 (28%) were asymptomatic, 34 (63%) had mild infections and 5 (10%) moderate, severe or critical infections. No patients died and only three patients required intensive care support due to COVID-19. Estimated incidence of hospital identified SARS-CoV-2 infection in children with cancer under 16 was 3%. Children with cancer with SARS-CoV-2 infection do not appear at increased risk of severe infection compared to the general paediatric population. This is reassuring and supports the continued delivery of standard treatment.
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影响因子：
36.4
作者：
Goetzinger, Florian;Santiago-Garcia, Begona;Tebruegge, Marc
通讯作者：
Tebruegge, Marc
2001 - 2007年，英格兰族裔的儿童癌症发生率：一项描述性流行病学研究。
影响因子：
3.8
作者：
Sayeed S;Barnes I;Ali R
通讯作者：
Ali R
影响因子：
3.7
作者：
Arevalo-Rodriguez I;Buitrago-Garcia D;Simancas-Racines D;Zambrano-Achig P;Del Campo R;Ciapponi A;Sued O;Martinez-García L;Rutjes AW;Low N;Bossuyt PM;Perez-Molina JA;Zamora J
通讯作者：
Zamora J
影响因子：
20.3
作者：
O'Connor, David;Bate, Jessica;Samarasinghe, Sujith
通讯作者：
Samarasinghe, Sujith
影响因子：
56.3
作者：
Qiu, Haiyan;Wu, Junhua;Chen, Dong
通讯作者：
Chen, Dong