Childhood cancer incidence by ethnic group in England, 2001-2007: a descriptive epidemiological study.
Childhood cancer incidence by ethnic group in England, 2001-2007: a descriptive epidemiological study.
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2001 - 2007年，英格兰族裔的儿童癌症发生率：一项描述性流行病学研究。
DOI：
10.1186/s12885-017-3551-7
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发表时间：
2017-08-25
期刊：
影响因子：
3.8
通讯作者：
Ali R
中科院分区：
文献类型：
--
作者：
Sayeed S;Barnes I;Ali R
在一岁之后，癌症是儿童最常见的死亡原因。不同族裔群体的发病率各不相同，最近数据联系方面的进展使人们能够更准确地估计这些差异。确定这些差异可能有助于确定某些儿童癌症的潜在风险或保护因素。因此，这项研究的目的是利用过去七年的全国数据来确定这种差异是否确实存在，就像之前在成人癌症中所描述的那样。我们获得了2001年1月至2007年12月英国所有儿童（0-14岁）癌症登记的数据。通过与医院事件统计数据库或癌症登记数据的记录联系来确定种族（自我分配）。根据国际儿童癌症分类，癌症在形态学上被分为四组：白血病；淋巴瘤;中枢神经系统；以及其他实体肿瘤。估计了每个种族的年龄标准化发病率，以及比较每个种族（印度人、巴基斯坦人、孟加拉国人、非洲黑人、加勒比黑人、中国人）与白人的发病率比，并对性别、年龄和贫困进行了调整。研究中的大多数孩子都是在英国出生的。黑人儿童（RR = 1.18, 99% CI: 1.01-1.39）和南亚人中，巴基斯坦儿童（RR = 1.19, 99% CI: 1.02-1.39）似乎所有癌症的风险都增加了。南亚儿童患白血病的风险增加（RR = 1.31, 99% CI: 1.08-1.58），黑人儿童（RR = 1.72, 99% CI: 1.13-2.63）和南亚儿童（RR = 1.51, 99% CI: 1.10-2.06）患淋巴瘤的风险增加。南亚人患中枢神经系统癌症的风险较低（RR = 0.71, 99% CI: 0.54-0.95）。在过去移民研究的传统中，这种对少数民族群体的描述性研究可以更好地了解人口中的疾病发病率，但也允许产生假设，以开始理解为什么存在这种差异。虽然儿童癌症是这一年龄组死亡的主要原因，但它仍然是一种相对罕见的疾病；然而，这里使用的方法已经允许第一次全国范围内对单个种族群体的儿童癌症进行估计。本文的在线版本（doi:10.1186/s12885-017-3551-7）包含补充材料，授权用户可以使用。
After the first year of life, cancers are the commonest cause of death in children. Incidence rates vary between ethnic groups, and recent advances in data linkage allow for a more accurate estimation of these variations. Identifying such differences may help identify potential risk or protective factors for certain childhood cancers. This study thus aims to ascertain whether such differences do indeed exist using nationwide data across seven years, as have previously been described in adult cancers. We obtained data for all cancer registrations for children (aged 0–14) in England from January 2001 to December 2007. Ethnicity (self-assigned) was established through record linkage to the Hospital Episodes Statistics database or cancer registry data. Cancers were classified morphologically according to the International Classification of Childhood Cancer into four groups – leukaemias; lymphomas; central nervous system; and other solid tumours. Age standardised incidence rates were estimated for each ethnic group, as well as incidence rate ratios comparing each individual ethnic group (Indian, Pakistani, Bangladeshi, Black African, Black Carribean, Chinese) to Whites, adjusting for sex, age and deprivation. The majority of children in the study are UK born. Black children (RR = 1.18, 99% CI: 1.01–1.39), and amongst South Asians, Pakistani children (RR = 1.19, 99% CI: 1.02–1.39) appear to have an increased risk of all cancers. There is an increased risk of leukaemia in South Asians (RR = 1.31, 99% CI: 1.08–1.58), and of lymphoma in Black (RR = 1.72, 99% CI: 1.13–2.63) and South Asian children (RR = 1.51, 99% CI: 1.10–2.06). South Asians appear to have a decreased risk of CNS cancers (RR = 0.71, 99% CI: 0.54–0.95). In the tradition of past migrant studies, such descriptive studies within ethnic minority groups permit a better understanding of disease incidence within the population, but also allow for the generation of hypotheses to begin to understand why such differences might exist. Though a major cause of mortality in this age group, childhood cancer remains a relatively rare disease; however, the methods used here have permitted the first nationwide estimation of childhood cancer by individual ethnic group. The online version of this article (doi:10.1186/s12885-017-3551-7) contains supplementary material, which is available to authorized users.
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影响因子：
120.7
作者：
Biggar, RJ;Frisch, M;Goedert, JJ
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