Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey.
Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey.
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DOI：
10.1038/s41598-022-24316-0
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发表时间：
2022-11-19
影响因子：
4.6
通讯作者：
Needham, Belinda L.
中科院分区：
文献类型：
--
作者：
Roberts, Emily K.;Boss, Jonathan;Mukherjee, Bhramar;Salerno, Stephen;Zota, Ami;Needham, Belinda L.
尽管在衰老和过早死亡疾病方面存在种族差异，但非西班牙裔美国黑人的白细胞端粒长度（LTL）（细胞衰老的生物标志物）往往比非西班牙裔白色美国人更长。先前的研究结果表明，接触某些持久性有机污染物（POP）既有种族模式，又与更长的LTL有关。我们研究是否黑色/白色的LTL的差异是由暴露于15种持久性有机污染物的差异来解释，估计间接影响（IE）的自我报告的种族对LTL介导的9个多氯联苯（PCBs），三个呋喃，三个二恶英，以及它们的混合物。我们的研究人群包括1999-2000年和2001-2002年全国健康和营养调查的1,251名成年人。我们通过构建调查加权线性回归模型来表征单污染物的中介效应。我们还实施了各种方法来量化所有持久性有机污染物的全球中介效应，包括无惩罚线性回归，岭回归和三个汇总暴露分数的检查。我们发现支持的假设，暴露于多氯联苯部分介导的黑色/白色差异的LTL。在单一污染物模型中，通过6个单独的多氯联苯（118，138，153，170，180和187）的LTL有显着的种族IE。岭回归（0.013，CI 0.001，0.023; 26.0%介导）和检查总结性暴露评分的模型，线性组合来自主成分分析（0.019，CI 0.009，0.029; 34.8%介导）和毒性等效商（TEQ）评分（0.016，CI 0.005，0.026; 28.8%介导）显示，当纳入调查权重时，存在显著的IE。暴露于个别持久性有机污染物及其混合物，这可能会引起居住和职业隔离，可能有助于解释为什么美国黑人有更长的LTL比他们的白色同行，提供了一个环境的解释违反直觉的种族差异在细胞老化。
Despite racial disparities in diseases of aging and premature mortality, non-Hispanic Black Americans tend to have longer leukocyte telomere length (LTL), a biomarker of cellular aging, than non-Hispanic White Americans. Previous findings suggest that exposure to certain persistent organic pollutants (POPs) is both racially-patterned and associated with longer LTL. We examine whether Black/White differences in LTL are explained by differences in exposure to 15 POPs by estimating the indirect effect (IE) of self-reported race on LTL that is mediated through nine polychlorinated biphenyls (PCBs), three furans, and three dioxins, as well as their mixtures. Our study population includes 1,251 adults from the 1999–2000 and 2001–2002 cycles of the cross-sectional National Health and Nutrition Examination Survey. We characterized single-pollutant mediation effects by constructing survey-weighted linear regression models. We also implemented various approaches to quantify a global mediation effect of all POPs, including unpenalized linear regression, ridge regression, and examination of three summary exposure scores. We found support for the hypothesis that exposure to PCBs partially mediates Black/White differences in LTL. In single-pollutant models, there were significant IEs of race on LTL through six individual PCBs (118, 138, 153, 170, 180, and 187). Ridge regression (0.013, CI 0.001, 0.023; 26.0% mediated) and models examining summative exposure scores with linear combinations derived from principal components analysis (0.019, CI 0.009, 0.029; 34.8% mediated) and Toxic Equivalency Quotient (TEQ) scores (0.016, CI 0.005, 0.026; 28.8% mediated) showed significant IEs when incorporating survey weights. Exposures to individual POPs and their mixtures, which may arise from residential and occupational segregation, may help explain why Black Americans have longer LTL than their White counterparts, providing an environmental explanation for counterintuitive race differences in cellular aging.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.2190/ns.20.2.e
发表时间：
2010
期刊：
New solutions : a journal of environmental and occupational health policy : NS
影响因子：
--
作者：
Angelon-Gaetz KA;Richardson DB;Wing S
通讯作者：
Wing S
影响因子：
3.5
作者：
Daniel M;Peek GW;Tollefsbol TO
通讯作者：
Tollefsbol TO
影响因子：
14.9
作者：
Cawthon, RM
通讯作者：
Cawthon, RM