Circadian rhythms, diet, and neuronal excitability.

Circadian rhythms, diet, and neuronal excitability.
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DOI:
10.1111/j.1528-1167.2008.01856.x
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发表时间:
2008-11
期刊:
影响因子:
5.6
通讯作者:
Allen CN
Allen CN
中科院分区:
医学1区
文献类型:
--
作者:
Allen CN

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正常生物功能的许多方面受昼夜节律的控制,包括新陈代谢、摄食行为和睡眠-觉醒周期。某些病理过程也会受到昼夜节律的影响。例如,众所周知,癫痫的发生会受到睡眠-觉醒周期的影响。生酮饮食(KD)是一种高脂肪、低碳水化合物的饮食,在治疗顽固性癫痫方面已被证明有效。虽然KD的临床效应的潜在机制尚不清楚,但在昼夜节律和KD作用之间出现了新的联系。在计划和实施KD时,应考虑这些因素。
Many aspects of normal biological function are governed by circadian rhythms, including metabolism, ingestive behaviors, and sleep-wake cycles. Certain pathological processes as well are also affected by circadian rhythms. For example, it is well known that seizure occurrence can be influenced by the sleep-wake cycle. The ketogenic diet (KD) is a high-fat, low-carbohydrate diet with proven efficacy in the treatment of intractable epilepsies. While the mechanisms underlying the clinical effects of the KD remain unclear, there are emerging links between circadian rhythms and KD action. Such factors should be considered when planning and administering the KD to patients.
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