Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice.
Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice.
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DOI：
10.1016/j.physbeh.2010.10.017
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发表时间：
2011-04-18
影响因子：
2.9
通讯作者：
Benoit, Stephen C.
中科院分区：
文献类型：
--
作者：
Davis, Jon F.;Choi, Derrick L.;Clegg, Deborah J.;Benoit, Stephen C.
预测特定膳食的能力部分是通过学习与预测营养可用性的刺激的关联来实现的。胃饥饿素是一种由肠道和大脑产生的食欲肽，在预期的进餐前升高，并且已经表明餐前胃饥饿素增加可以作为预测进餐递送的信号。在这里，我们使用野生型和生长激素释放肽受体缺陷小鼠来测试生长激素释放肽信号传导对于处理情感相关刺激、空间学习和习惯性进食反应是必要的这一假设。我们分别用Morris水迷宫和避暗被动回避试验测试空间和恐惧相关记忆，并在两周的膳食喂养范例后利用食物预期活动监测习惯性喂养反应。我们的研究结果表明，ghrelin信号调节空间记忆的表现，是必要的食物预期活动的发展。总的来说，这些结果表明，生长激素释放肽受体信号是必要的适应预期的反应，伴随着限制喂养。
The ability to predict a particular meal is achieved in part by learned associations with stimuli that predict nutrient availability. Ghrelin is an orexigenic peptide produced by both the gut and brain that rises before anticipated meals and it has been suggested that pre-prandial ghrelin increases may act as a signal to predict meal delivery. Here, we used wild type and ghrelin receptor deficient mice to test the hypothesis that ghrelin signaling is necessary for the processing of emotionally relevant stimuli, spatial learning and habituated feeding responses. We tested spatial and fear-related memory with the morris water maze and step through passive avoidance tests, respectively and utilized food anticipatory activity to monitor habituated feeding responses following two weeks of a meal feeding paradigm. Our results indicate that ghrelin signaling modulates spatial memory performance and is necessary for the development of food anticipatory activity. Collectively, these results suggest that ghrelin receptor signaling is necessary for adaptations in the anticipatory responses that accompany restricted feeding.
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影响因子：
2.9
作者：
Petrovich, Gorica D.;Gallagher, Michela
通讯作者：
Gallagher, Michela
与食物相关的提示改变了前脑功能连通性，如直接的早期基因和原晶蛋白表达所评估。
影响因子：
5.4
作者：
Schiltz CA;Bremer QZ;Landry CF;Kelley AE
通讯作者：
Kelley AE
影响因子：
2.9
作者：
Poulin, Anne-Marie;Tirnofeeva, Elena
通讯作者：
Tirnofeeva, Elena
影响因子：
3.3
作者：
Mendoza, J;Angeles-Castellanos, M;Escobar, C
通讯作者：
Escobar, C
影响因子：
16.2
作者：
Cowley, MA;Smith, RG;Horvath, TL
通讯作者：
Horvath, TL