Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease.
Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease.
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炎症引发肥胖和非酒精性脂肪肝之间的恶性循环。
DOI：
10.1002/iid3.391
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Lin H
中科院分区：
文献类型：
--
作者：
Luo Y;Lin H
低水平的慢性炎症激活是肥胖的特征。非酒精性脂肪性肝病（NAFLD）与肥胖密切相关，是一种新兴的健康问题，其起源于肝脏中甘油三酯的异常积累，有时会引起炎症反应，可能导致肝硬化和肝癌，因此需要阐明其发病机制以提供更多治疗选择。 NAFLD一旦形成，就会导致全身炎症，在NAFLD期间持续维持低度炎症，导致肥胖症炎症消退受损，从而加剧其严重程度。这项研究的重点是肥胖引起的炎症的影响，这是疾病进展和发展为更严重的炎症和纤维化阶段的根本原因。了解肥胖与 NAFLD 之间的关系有助于在肥胖引起的炎症反应中建立有吸引力的治疗靶点或诊断标志物，并为肥胖引起的 NAFLD 的预防和治疗提供新方法。肥胖通过影响脂肪组织、血管、肠道、骨骼肌和大脑的多种炎症反应，在相关非酒精性脂肪肝的发展中起着至关重要的作用，这一过程与脂肪组织炎症、血液中的炎症因子、肠道炎症、骨骼肌炎症和脑组织炎症有关。
Low‐level of chronic inflammation activation is characteristic of obesity. Nonalcoholic fatty liver disease (NAFLD) is closely linked to obesity and is an emerging health problem, it originates from abnormal accumulation of triglycerides in the liver, and sometimes causes inflammatory reactions that could contribute to cirrhosis and liver cancer, thus its pathogenesis needs to be clarified for more treatment options. Once NAFLD is established, it contributes to systemic inflammation, the low‐grade inflammation is continuously maintained during NAFLD causing impaired resolution of inflammation in obesity, which subsequently exacerbates its severity. This study focuses on the effects of obesity‐induced inflammations, which are the underlying causes of the disease progression and development of more severe inflammatory and fibrotic stages. Understanding the relationship between obesity and NAFLD could help in establishing attractive therapeutic targets or diagnostic markers in obesity‐induced inflammation response and provides new approaches for the prevention and treatment of NAFLD in obesity. Obesity plays a vital role in the development of associated nonalcoholic fatty liver disease by affecting several inflammatory reactions via adipose tissue, vascular, intestinal, skeletal muscle, and brain, this process is associated with adipose tissue inflammation, inflammatory factors in the blood, intestinal inflammation, skeletal muscle inflammation, and brain tissue inflammation.
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影响因子：
5.2
作者：
Choe SS;Huh JY;Hwang IJ;Kim JI;Kim JB
通讯作者：
Kim JB
影响因子：
4.3
作者：
Chao CY;Battat R;Al Khoury A;Restellini S;Sebastiani G;Bessissow T
通讯作者：
Bessissow T
影响因子：
15.9
作者：
Donnelly, KL;Smith, CI;Parks, EJ
通讯作者：
Parks, EJ
DOI：
10.2147/dmso.s219363
发表时间：
2019-01-01
期刊：
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
影响因子：
--
作者：
Chen, Haishan;Xiong, Chongxiang;Zou, Hequn
通讯作者：
Zou, Hequn
影响因子：
3.7
作者：
Ding SZ;Fischer W;Kaparakis-Liaskos M;Liechti G;Merrell DS;Grant PA;Ferrero RL;Crowe SE;Haas R;Hatakeyama M;Goldberg JB
通讯作者：
Goldberg JB