Predicting thrombotic cardiovascular outcomes induced by waterpipe-associated chemicals using comparative toxicogenomic database: Genes, phenotypes, and pathways.
Predicting thrombotic cardiovascular outcomes induced by waterpipe-associated chemicals using comparative toxicogenomic database: Genes, phenotypes, and pathways.
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DOI：
10.1016/j.lfs.2023.121694
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发表时间：
2023-06-15
期刊：
影响因子：
6.1
通讯作者：
Khasawneh, Fadi T.
中科院分区：
文献类型：
--
作者：
Alarabi, Ahmed B.;Mohsen, Attayab;Ben Taleb, Ziyad;Mizuguchi, Kenji;Alshbool, Fatima Z.;Khasawneh, Fadi T.
水烟袋，或称水烟管，是一种在美国流行的吸烟装置。越来越多的证据表明，水管烟雾（WPS）与对人类健康的各种不良影响有关，包括传染病，癌症和心血管疾病（CVD），特别是血栓形成事件。然而，WPS促进疾病发展的分子机制仍不清楚。在本研究中，我们利用基于比较毒理基因组学数据库（CTD）的分析方法，整合化学、基因、表型和疾病数据，根据其化学和毒物特征预测WPS影响的潜在分子机制。我们的分析显示，就与WPS化学品的策划相互作用的数量而言，CVD是最常见的疾病类别之一。我们确定了5674个基因之间的共同调制WPS化学品和传统的烟草吸烟。与WPS化学品发生最多协同相互作用的CVD是高血压、动脉粥样硬化和心肌梗死，而“颗粒物”、“重金属”和“尼古丁”与CVD发生协同相互作用的数量最多。我们的分析预测，WPS诱导的血栓性疾病的潜在机制涉及常见的表型，如炎症，凋亡和细胞增殖，这是所有血栓性疾病和上述三种化学物质共有的。在丰富的信号传导途径方面，我们确定了几个，包括趋化因子和MAPK信号传导，其中颗粒物与WPS化学品相关的所有12个重要信号传导途径表现出最具统计学意义的相关性。总的来说，我们的预测性综合分析提供了WPS对健康产生负面影响的证据，并提供了对其发挥这些影响的潜在机制的见解。这些信息应该指导进一步的研究，以探索和更好地了解WPS和其他烟草产品相关的健康后果。
Hookah, or waterpipe, is a tobacco smoking device that has gained popularity in the United States. A growing body of evidence demonstrates that waterpipe smoke (WPS) is associated with various adverse effects on human health, including infectious diseases, cancer, and cardiovascular diseases (CVDs), particularly thrombotic events. However, the molecular mechanisms through which WPS contributes to disease development remain unclear. In this study, we utilized an analytical approach based on the Comparative Toxicogenomics Database (CTD) to integrate chemical, gene, phenotype, and disease data to predict potential molecular mechanisms underlying the effects of WPS, based on its chemical and toxicant profile. Our analysis revealed that CVDs were among the top disease categories with regard to the number of curated interactions with WPS chemicals. We identified 5674 genes common between those modulated by WPS chemicals and traditional tobacco smoking. The CVDs with the most curated interactions with WPS chemicals were hypertension, atherosclerosis, and myocardial infarction, whereas “particulate matter”, “heavy metals”, and “nicotine” showed the highest number of curated interactions with CVDs. Our analysis predicted that the potential mechanisms underlying WPS-induced thrombotic diseases involve common phenotypes, such as inflammation, apoptosis, and cell proliferation, which are shared across all thrombotic diseases and the three aforementioned chemicals. In terms of enriched signaling pathways, we identified several, including chemokine and MAPK signaling, with particulate matter exhibiting the most statistically significant association with all 12 significant signaling pathways related to WPS chemicals. Collectively, our predictive comprehensive analysis provides evidence that WPS negatively impacts health and offers insights into the potential mechanisms through which it exerts these effects. This information should guide further research to explore and better understand the WPS and other tobacco product-related health consequences.
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影响因子：
2
作者：
Ajab, Huma;Yasmeen, Sadia;Malik, Salman Akbar
通讯作者：
Malik, Salman Akbar
影响因子：
4.7
作者：
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Eissenberg, Thomas
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影响因子：
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通讯作者：
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影响因子：
2.1
作者：
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Eissenberg, Thomas
影响因子：
120.7
作者：
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通讯作者：
Hennekens, CH