Maternal ambient air pollution exposure preconception and during early gestation and offspring congenital orofacial defects.
Maternal ambient air pollution exposure preconception and during early gestation and offspring congenital orofacial defects.
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DOI：
10.1016/j.envres.2015.06.002
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发表时间：
2015-07
影响因子：
8.3
通讯作者：
Mendola, Pauline
中科院分区：
文献类型：
--
作者：
Zhu, Yeyi;Zhang, Cuilin;Liu, Danping;Grantz, Katherine L.;Wallace, Maeve;Mendola, Pauline
母亲的空气污染暴露与口面部裂有关，但文献的说法是模棱两可的。尚未研究潜在的慢性孕前影响。研究了孕前三个月和妊娠第 3-8 周期间空气污染物暴露与口面部缺陷的关系。在安全劳动联盟 (2002-2008) 的 188,102 例活产和胎儿死亡中，63 例患有孤立性腭裂 (CP)，159 例患有孤立性唇裂伴或不伴腭裂 (CL ± CP)。使用修改后的社区多尺度空气质量模型估算暴露量。根据地点/区域和母亲人口统计、生活方式和临床因素调整广义估计方程的逻辑回归计算出每种污染物每四分位数增加的比值比 (OR) 和 95% CI。孕前、一氧化碳（CO；OR = 2.24；CI：1.21、4.16）和颗粒物（PM）≤10 μm（OR = 1.72；CI：1.12、2.66）与 CP 显着相关，而二氧化硫（SO2）与 CL ± CP 相关（OR = 1.93；CI：1.16、3.21）。在妊娠第 3-8 周，CO 仍然是 CP 的显着风险（OR = 2.74；CI：1.62，4.62），氮氧化物（NOx；OR = 3.64；CI：1.73，7.66）和 PM ≤ 2.5 μm（PM2.5；OR = 1.74；CI：1.15，2.64）也与该风险相关。按周进行的分析表明，NOx 和 PM2.5 与 CP 的正相关性分别在第 3-6 周和第 3-5 周最为突出。孕前和妊娠早期暴露于多种标准空气污染物与 CP 发生几率升高相关，而 CL ± CP 仅与孕前 SO2 暴露相关。
Maternal air pollution exposure has been related to orofacial clefts but the literature is equivocal. Potential chronic preconception effects have not been studied. Criteria air pollutant exposure during three months preconception and gestational weeks 3–8 was studied in relation to orofacial defects. Among 188,102 live births and fetal deaths from the Consortium on Safe Labor (2002–2008), 63 had isolated cleft palate (CP) and 159 had isolated cleft lip with or without cleft palate (CL ± CP). Exposures were estimated using a modified Community Multiscale Air Quality model. Logistic regression with generalized estimating equations adjusted for site/region and maternal demographic, lifestyle and clinical factors calculated the odds ratio (OR) and 95% CI per interquartile increase in each pollutant. Preconception, carbon monoxide (CO; OR = 2.24; CI: 1.21, 4.16) and particulate matter (PM) ≤10 μm (OR = 1.72; CI: 1.12, 2.66) were significantly associated with CP, while sulfur dioxide (SO2) was associated with CL ± CP (OR = 1.93; CI: 1.16, 3.21). During gestational weeks 3–8, CO remained a significant risk for CP (OR = 2.74; CI: 1.62, 4.62) and nitrogen oxides (NOx; OR = 3.64; CI: 1.73, 7.66) and PM ≤2.5 μm (PM2.5; OR = 1.74; CI: 1.15, 2.64) were also related to the risk. Analyses by individual week revealed that positive associations of NOx and PM2.5 with CP were most prominent from weeks 3–6 and 3–5, respectively. Exposure to several criteria air pollutants preconception and during early gestation was associated with elevated odds for CP, while CL ± CP was only associated with preconception SO2 exposure.
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