Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization.
Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization.
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DOI：
10.1038/s41522-023-00430-3
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发表时间：
2023-08-28
影响因子：
9.2
通讯作者：
Malecki KMC
中科院分区：
文献类型：
--
作者：
Zuniga-Chaves I;Eggers S;Kates AE;Safdar N;Suen G;Malecki KMC
社会差距继续限制普遍获得保健，直接影响寿命和生活质量。与此同时，肠道微生物组与下游健康结果相关，包括全球抗生素耐药性的上升。然而，研究社会经济地位（SES）与肠道微生物组组成相关性的证据有限。为了解决这个问题，我们收集了来自美国威斯康星州的一个成年队列中社区水平SES、肠道微生物群和其他个体辅助因子的信息，包括多药耐药微生物（MDRO）的定植。我们发现SES和微生物组成之间的关联是由粮食不安全介导的。此外，我们观察到从具有低多样性微生物组和低邻域SES的个体中分离出的MDRO的患病率较高。我们的综合人群为基础的研究考虑了如何相互作用的几个社会和经济因素联合收割机结合起来，影响肠道微生物组成，同时提供了一个框架，制定未来的干预措施，以帮助减轻SES的健康差距。
Social disparities continue to limit universal access to health care, directly impacting both lifespan and quality of life. Concomitantly, the gut microbiome has been associated with downstream health outcomes including the global rise in antibiotic resistance. However, limited evidence exists examining socioeconomic status (SES) associations with gut microbiome composition. To address this, we collected information on the community-level SES, gut microbiota, and other individual cofactors including colonization by multidrug-resistant organisms (MDROs) in an adult cohort from Wisconsin, USA. We found an association between SES and microbial composition that is mediated by food insecurity. Additionally, we observed a higher prevalence of MDROs isolated from individuals with low diversity microbiomes and low neighborhood SES. Our integrated population-based study considers how the interplay of several social and economic factors combine to influence gut microbial composition while providing a framework for developing future interventions to help mitigate the SES health gap.
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