Canine and murine models of osteosarcoma.
Canine and murine models of osteosarcoma.
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DOI：
10.1177/03009858221083038
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发表时间：
2022-05
影响因子：
2.4
通讯作者：
中科院分区：
文献类型：
--
作者：
骨肉瘤（OS）是儿童最常见的恶性骨肿瘤。尽管努力开发和实施新疗法，但自 20 世纪 80 年代以来，患者的治疗效果并没有明显改善。转移仍然是患者死亡的主要来源，30% 的病例在诊断后 5 年内出现转移性疾病。研究模型对于癌症研究的进步至关重要，并且包括多种物种。例如，异种移植和患者来源的异种移植（PDX）小鼠模型提供了在体内研究人类肿瘤细胞的机会，而转基因模型则为了解操作系统发育的分子机制提供了重要的见解。人们对伴侣物种中自然发生的癌症的认识不断加深，人们对兽医患者如何为癌症生物学和药物开发研究做出贡献有了新的见解。对犬类病例的研究，包括使用诊断组织档案和临床试验，为进一步犬类和人类癌症研究提供了潜在的机制。操作系统研究领域的进步需要动物模型的持续开发和适当使用。在这篇综述中，描述了 OS 的动物模型，重点是小鼠和携带肿瘤的宠物狗，作为人类 OS 的平行和补充模型。
Osteosarcoma (OS) is the most common malignant bone tumor in children. Despite efforts to develop and implement new therapies, patient outcomes have not measurably improved since the 1980s. Metastasis continues to be the main source of patient mortality, with 30% of cases developing metastatic disease within 5 years of diagnosis. Research models are critical in the advancement of cancer research and include a variety of species. For example, xenograft and patient-derived xenograft (PDX) mouse models provide opportunities to study human tumor cells in vivo while transgenic models have offered significant insight into the molecular mechanisms underlying OS development. A growing recognition of naturally occurring cancers in companion species has led to new insights into how veterinary patients can contribute to studies of cancer biology and drug development. The study of canine cases, including the use of diagnostic tissue archives and clinical trials, offers a potential mechanism to further canine and human cancer research. Advancement in the field of OS research requires continued development and appropriate use of animal models. In this review, animal models of OS are described with a focus on the mouse and tumor-bearing pet dog as parallel and complementary models of human OS.
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影响因子：
2.4
作者：
Barger, A;Graca, R;Hoffmann, W
通讯作者：
Hoffmann, W
影响因子：
1.1
作者：
Cesario, L.;Garrett, L. D.;Fan, T. M.
通讯作者：
Fan, T. M.
影响因子：
3.7
作者：
Angstadt, Andrea Y.;Motsinger-Reif, Alison;Breen, Matthew
通讯作者：
Breen, Matthew
影响因子：
64.8
作者：
DONEHOWER, LA;HARVEY, M;BRADLEY, A
通讯作者：
BRADLEY, A
DOI：
10.1073/pnas.0805462105
发表时间：
2008-08-19
影响因子：
11.1
作者：
Berman, Seth D.;Calo, Eliezer;Lees, Jacqueline A.
通讯作者：
Lees, Jacqueline A.