Spatial dependencies between large-scale brain networks.
Spatial dependencies between large-scale brain networks.
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DOI：
10.1371/journal.pone.0098500
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Sharp DJ
中科院分区：
文献类型：
--
作者：
Leech R;Scott G;Carhart-Harris R;Turkheimer F;Taylor-Robinson SD;Sharp DJ
功能性神经影像学揭示了许多任务中神经激活的增加（任务积极）和减少（任务消极）。许多研究表明，任务积极和任务消极网络之间的时间关系，是有效的认知功能的重要。在这里，我们提供的空间关系任务的积极和消极的网络的证据。在许多已报道的任务负性脑网络之间存在很强的空间相似性，称为默认模式网络，通常被认为是空间固定的网络。然而，事实并非如此。DMN的空间结构根据正在执行的具体任务而变化。我们测试是否有一个基本的空间关系之间的任务积极和消极的网络。具体来说，我们假设，任务的积极和消极的体素之间的距离是一致的，尽管不同的空间模式的激活和失活诱发不同的认知任务。我们显示显着减少的变化，在条件内的任务积极和任务负体素之间的距离比跨条件的距离为四个不同的感觉，运动和认知任务-这意味着失活模式是空间依赖于激活模式（反之亦然），这两个调制特定的任务需求。我们还显示了在没有特定任务的情况下，来自第三个“休息”数据集的正相关和负相关网络之间的类似关系。我们建议，这种空间关系可能是宏观模拟的微观神经元组织中的感觉皮层系统的报告，这种组织可能反映了有效的大脑功能所必需的稳态可塑性。
Functional neuroimaging reveals both increases (task-positive) and decreases (task-negative) in neural activation with many tasks. Many studies show a temporal relationship between task positive and task negative networks that is important for efficient cognitive functioning. Here we provide evidence for a spatial relationship between task positive and negative networks. There are strong spatial similarities between many reported task negative brain networks, termed the default mode network, which is typically assumed to be a spatially fixed network. However, this is not the case. The spatial structure of the DMN varies depending on what specific task is being performed. We test whether there is a fundamental spatial relationship between task positive and negative networks. Specifically, we hypothesize that the distance between task positive and negative voxels is consistent despite different spatial patterns of activation and deactivation evoked by different cognitive tasks. We show significantly reduced variability in the distance between within-condition task positive and task negative voxels than across-condition distances for four different sensory, motor and cognitive tasks - implying that deactivation patterns are spatially dependent on activation patterns (and vice versa), and that both are modulated by specific task demands. We also show a similar relationship between positively and negatively correlated networks from a third ‘rest’ dataset, in the absence of a specific task. We propose that this spatial relationship may be the macroscopic analogue of microscopic neuronal organization reported in sensory cortical systems, and that this organization may reflect homeostatic plasticity necessary for efficient brain function.
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影响因子：
3.7
作者：
Harrison BJ;Pujol J;Contreras-Rodríguez O;Soriano-Mas C;López-Solà M;Deus J;Ortiz H;Blanco-Hinojo L;Alonso P;Hernández-Ribas R;Cardoner N;Menchón JM
通讯作者：
Menchón JM
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
9.9
作者：
McPhail, Mark J. W.;Leech, Robert;Taylor-Robinson, Simon D.
通讯作者：
Taylor-Robinson, Simon D.
DOI：
10.1523/jneurosci.2111-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
He BJ
通讯作者：
He BJ
影响因子：
3.8
作者：
Seghier ML;Price CJ
通讯作者：
Price CJ