Task-induced deactivation from rest extends beyond the default mode brain network.
Task-induced deactivation from rest extends beyond the default mode brain network.
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DOI：
10.1371/journal.pone.0022964
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Menchón JM
中科院分区：
文献类型：
--
作者：
Harrison BJ;Pujol J;Contreras-Rodríguez O;Soriano-Mas C;López-Solà M;Deus J;Ortiz H;Blanco-Hinojo L;Alonso P;Hernández-Ribas R;Cardoner N;Menchón JM
在人类功能性神经成像研究中，经常观察到中线和顶叶皮质脑区域的活动减少或失活，这些研究比较了基于任务的认知表现与被动状态（如休息）的时期。现在人们普遍认为，这种由任务引起的失活是一个高度组织化的“默认模式网络”（DMN）的标志：DMN是一个大规模的大脑系统，其发现对人类大脑功能和行为的研究具有广泛的意义。在这项工作中，我们发现，常见的任务引起的失活从休息也发生以外的DMN作为增加的任务需求的函数。50名健康成年受试者进行了两项不同的功能磁共振成像任务，旨在可靠地映射从静息基线失活。作为主要的研究结果，任务需求的增加一贯调制区域解剖DMN失活。在高水平的任务需求，强大的失活观察非DMN地区，最值得注意的是，后岛叶皮层。该区域的失活直接涉及基于性能的分析经验丰富的任务难度。总之，这些发现表明，任务引起的失活从休息不仅限于DMN和扩展到大脑区域通常与综合感觉和内感受过程。
Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized ‘default-mode network’ (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
14.5
作者：
Bantick, SJ;Wise, RG;Tracey, I
通讯作者：
Tracey, I
影响因子：
2.5
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
DOI：
10.1523/jneurosci.4004-09.2009
发表时间：
2009-11-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Laird AR;Eickhoff SB;Li K;Robin DA;Glahn DC;Fox PT
通讯作者：
Fox PT
影响因子：
2.5
作者：
Hutchinson, M;Schiffer, W;Brodie, JD
通讯作者：
Brodie, JD