Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System.
Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System.
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具有滥用责任的鸦片药物劫持了内源性阿片类药物系统，以破坏中枢神经系统中的神经元和神经胶质成熟。
DOI：
10.3389/fped.2017.00294
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发表时间：
2017
影响因子：
2.6
通讯作者：
Knapp PE
中科院分区：
文献类型：
--
作者：
Hauser KF;Knapp PE
内源性阿片系统由多个阿片神经肽和受体基因家族组成，由发育中的神经细胞高度表达，并能显著影响神经元和神经胶质的成熟。在许多中枢神经系统(CNS)区域，阿片肽和受体的表达只在发育过程中短暂发生，随着随后的成熟而有效地消失，只有在病理条件下才会重新出现，例如炎症或损伤。有滥用倾向的阿片类药物通过模仿内源性阿片类药物的行为来改变生长和发育。虽然阿片类药物通常由μ-阿片受体介导，但也可以通过δ-和κ-阿片受体以细胞类型、区域特异性和发育调节的方式调节生长。阿片类药物作为生物反应调节剂，其作用是高度上下文的、可塑性的、可改变的，并受到其他生理过程或病理生理条件的影响，如神经获得性免疫缺陷综合征。到目前为止，大多数研究都考虑了鸦片类药物对细胞成熟的急性影响。例如，激活阿片受体通常会导致神经元和胶质细胞的急性生长抑制。然而，随着持续的阿片类药物暴露，代偿因素开始发挥作用，这一概念在中枢神经系统成熟过程中基本上被忽视了。因此，本文综述了阿片类药物对中枢神经系统成熟影响的研究现状，并对今后该领域的研究提出了新的方向。识别在成熟期对长期阿片类药物暴露的适应性反应(如耐受性)的细胞和分子机制对于理解围产期阿片类药物暴露对中枢神经系统的影响至关重要。
The endogenous opioid system, comprised of multiple opioid neuropeptide and receptor gene families, is highly expressed by developing neural cells and can significantly influence neuronal and glial maturation. In many central nervous system (CNS) regions, the expression of opioid peptides and receptors occurs only transiently during development, effectively disappearing with subsequent maturation only to reemerge under pathologic conditions, such as with inflammation or injury. Opiate drugs with abuse liability act to modify growth and development by mimicking the actions of endogenous opioids. Although typically mediated by μ-opioid receptors, opiate drugs can also act through δ- and κ-opioid receptors to modulate growth in a cell-type, region-specific, and developmentally regulated manner. Opioids act as biological response modifiers and their actions are highly contextual, plastic, modifiable, and influenced by other physiological processes or pathophysiological conditions, such as neuro-acquired immunodeficiency syndrome. To date, most studies have considered the acute effects of opiates on cellular maturation. For example, activating opioid receptors typically results in acute growth inhibition in both neurons and glia. However, with sustained opioid exposure, compensatory factors become operative, a concept that has been largely overlooked during CNS maturation. Accordingly, this article surveys prior studies on the effects of opiates on CNS maturation, and also suggests new directions for future research in this area. Identifying the cellular and molecular mechanisms underlying the adaptive responses to chronic opiate exposure (e.g., tolerance) during maturation is crucial toward understanding the consequences of perinatal opiate exposure on the CNS.
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影响因子：
3.4
作者：
Bora, Emre;Yuecel, Murat;Lubman, Dan I.
通讯作者：
Lubman, Dan I.
影响因子：
3.3
作者：
Arguello AA;Harburg GC;Schonborn JR;Mandyam CD;Yamaguchi M;Eisch AJ
通讯作者：
Eisch AJ
影响因子：
64.8
作者：
ALTMAN, J;DAS, GD
通讯作者：
DAS, GD
影响因子：
2.5
作者：
ALTMAN, J
通讯作者：
ALTMAN, J
影响因子：
2.9
作者：
BAKALKIN, GY;KOBYLYANSKY, AG
通讯作者：
KOBYLYANSKY, AG