Prolactin may serve as a regulator to promote vocal fold wound healing
Prolactin may serve as a regulator to promote vocal fold wound healing
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催乳素可能作为促进声带伤口愈合的调节剂
DOI：
10.1042/bsr20200467
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Xu Wen
中科院分区：
文献类型：
--
作者：
Wang Haizhou;Li Xueyan;Lu Jieyu;Jones Paul;Xu Wen
摘要减少的催乳素(PRL)已被证明延迟伤口愈合，但对其潜在机制的了解有限。在此，我们旨在探讨PRL在声带损伤修复中的作用。用基因芯片检测大鼠VF损伤后1、4、8周VF组织中PRL的表达水平，并与正常对照组比较。然后，进行了系统的生物信息学分析，探索了VF损伤修复过程中涉及的生物网络和信号通路。各VF损伤组(第1、4、8周)PRL的表达均显著低于对照组(F统计量=280.34；P=4.88e-14)，但3组间差异无统计学意义(F统计量=1.97；P=0.18)。创伤对促进和抑制PRL途径均有干扰作用，其中包括11种PRL抑制剂和6种PRL促进剂。我们的结果显示，VF损伤后PRL表达水平降低，不利于创面愈合。所确定的途径可能有助于理解PRL作为VF伤口愈合的治疗靶点的作用。
Abstract Reduced prolactin (PRL) has been shown to delay wound healing with a limited understanding of the underlying mechanisms. Here, we aim to explore the role of PRL in the repair of vocal fold (VF) injury. A microarray was used to detect the expressed levels of PRL in rat VF tissue at 1, 4, and 8 weeks after VF injury compared with normal uninjured rats. Then, a systematic bioinformatics analysis has been conducted to explore the literature-based biology network and signaling pathways involved in the repair of VF injury. The expression of PRL was significantly decreased in all VF injury groups (week 1, 4, and 8) compared with the control group (F stats = 280.34; P=4.88e-14), with no significant difference among the three VF injury groups (F stats = 1.97; P=0.18). Wounding has been shown to interfere with both PRL-promoting and inhibiting pathways that were involved in wound healing, including 11 PRL inhibitors and 6 PRL promoters. Our results reveal decreased PRL expression levels in VF injury, which is not in favor of the wound healing. The pathways identified may help in understanding the role of PRL as a treatment target for VF wound healing.
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