Caudate nucleus signals for breaches of expectation in a movement observation paradigm.
Caudate nucleus signals for breaches of expectation in a movement observation paradigm.
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DOI：
10.3389/fnhum.2011.00038
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发表时间：
2011
影响因子：
2.9
通讯作者：
Schubotz RI
中科院分区：
文献类型：
--
作者：
Schiffer AM;Schubotz RI
纹状体已被确定为奖赏相关预测误差的载体。这个预测误差信号涉及到预测了多少奖励和获得了多少奖励之间的差异。然而，纹状体是否也存在对预期的一般破坏，即知觉预测错误，这一点还有待确定。目前的研究使用功能磁共振成像(FMRI)来研究尾状核在违反预期中的作用。重要的是，违规行为与奖励的发生或缺失无关。在功能磁共振研究之前，参与者接受了训练，根据听觉线索产生一系列全身运动。在功能磁共振成像阶段，他们观看了一位舞者根据线索(88%)或不是(12%)产生相同序列的电影。尾状核被激活，以进行违反预测的运动。这种激活的侧翼是后上颞沟、颞顶交界处和相邻的角回的活动，该网络可能将偏离的运动传递到尾状核，而额区可能反映了当前预测的适应性调整。通过两个对照对照，可以排除对尾状核活动的另一种解释，无论是与违反预期的显著程度有关的，还是与行为适应有关的。研究结果支持这样一种观点，即尾状核中的神经元对违反预期的行为进行编码，并指向一个分布式网络，该网络参与检测、发送信号并针对违反的预测调整行为和预期。
The striatum has been established as a carrier of reward-related prediction errors. This prediction error signal concerns the difference between how much reward was predicted and how much reward is gained. However, it remains to be established whether general breaches of expectation, i.e., perceptual prediction errors, are also implemented in the striatum. The current study used functional magnetic resonance imaging (fMRI) to investigate the role of caudate nucleus in breaches of expectation. Importantly, breaches were not related to the occurrence or absence of reward. Preceding the fMRI study, participants were trained to produce a sequence of whole-body movements according to auditory cues. In the fMRI session, they watched movies of a dancer producing the same sequences either according to the cue (88%) or not (12%). Caudate nucleus was activated for the prediction-violating movements. This activation was flanked by activity in posterior superior temporal sulcus, the temporo-parietal junction and adjacent angular gyrus, a network that may convey the deviating movement to caudate nucleus, while frontal areas may reflect adaptive adjustments of the current prediction. Alternative interpretations of caudate activity relating either to the saliency of breaches of expectation or to behavioral adaptation could be excluded by two control contrasts. The results foster the notion that neurons in the caudate nucleus code for a breach in expectation, and point toward a distributed network involved in detecting, signaling and adjusting behavior and expectations toward violated prediction.
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影响因子：
4.3
作者：
Kiebel SJ;Daunizeau J;Friston KJ
通讯作者：
Friston KJ
影响因子：
2.9
作者：
Bubic A;von Cramon DY;Schubotz RI
通讯作者：
Schubotz RI
影响因子：
2.5
作者：
Bunge, SA;Kahn, I;Wagner, AD
通讯作者：
Wagner, AD
DOI：
10.1093/cercor/bhn161
发表时间：
2009-05
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
den Ouden HE;Friston KJ;Daw ND;McIntosh AR;Stephan KE
通讯作者：
Stephan KE
影响因子：
5.7
作者：
Lohmann, G;Müller, K;von Cramon, DY
通讯作者：
von Cramon, DY