An increase of phosphatidylcholines in follicular fluid implies attenuation of embryo quality on day 3 post-fertilization.
An increase of phosphatidylcholines in follicular fluid implies attenuation of embryo quality on day 3 post-fertilization.
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卵泡液中磷脂酰胆碱的增加意味着受精后第 3 天胚胎质量的下降
DOI：
10.1186/s12915-021-01118-w
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发表时间：
2021-09-09
期刊：
影响因子：
5.4
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Wang J;Zheng W;Zhang S;Yan K;Jin M;Hu H;Ma Z;Gong F;Lu G;Ren Y;Lin L;Lin G;Hu L;Liu S
虽然卵母细胞质量是决定胚胎质量的主要因素，但很少有研究基于与卵母细胞相关的代谢产物来评估胚胎质量。通过对辅助生殖技术（ART）中卵泡液（FF）代谢产物的定量分析，本研究试图通过一种信息性方法来评估胚胎或卵母细胞的质量。一个由17个特征组成的评估模型被用来区分受精后第3天的胚胎质量，磷脂酰胆碱（PC）是评估的关键因素。该模型扩展到不同年龄和超刺激下的患者，并进一步丰富了特征，以便于评估胚胎质量。代谢产物通过途径分析进行聚类，导致一个假设，花生四烯酸的积累诱导的PC可能会削弱胚胎质量在受精后第3天。建立了一个具有卵泡液代谢特征的判别模型，即使在某些临床条件下也能评价胚胎或卵母细胞的质量，卵泡液中PC的增加意味着受精后第3天胚胎质量的下降。在线版本包含补充材料，可通过10.1186/s12915-021-01118-w获得。
Although oocyte quality is the dominant factor determining embryo quality, few studies have been conducted to evaluate embryo quality based on the metabolites related to the oocyte. With quantification of the follicular fluid (FF) metabolites, in assisted reproductive technology (ART), this study sought to evaluate the embryo or oocyte quality through an informative approach. An evaluation model consisting of 17 features was generated to distinguish the embryo quality on day 3 post-fertilization, and phosphatidylcholines (PCs) were the key contributors to the evaluation. The model was extended to the patients under different ages and hyperstimulations, and the features were further enriched to facilitate the evaluation of the embryo quality. The metabolites were clustered through pathway analysis, leading to a hypothesis that accumulation of arachidonic acid induced by PCs might weaken embryo quality on day 3 post-fertilization. A discriminating model with metabolic features elicited from follicular fluid was established, which enabled the evaluation of the embryo or oocyte quality even under certain clinical conditions, and the increase of PCs in follicular fluid implies the attenuation of embryo quality on day 3 post-fertilization. The online version contains supplementary material available at 10.1186/s12915-021-01118-w.
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影响因子：
3.8
作者：
Adibhatla RM;Hatcher JF
通讯作者：
Hatcher JF
影响因子：
4
作者：
Botros L;Sakkas D;Seli E
通讯作者：
Seli E
影响因子：
6.1
作者：
Chiu, TTY;Rogers, MS;Haines, CJ
通讯作者：
Haines, CJ
DOI：
10.1073/pnas.98.4.1655
发表时间：
2001-02-13
影响因子：
11.1
作者：
Hardy, K;Spanos, S;Stark, J
通讯作者：
Stark, J
影响因子：
4.4
作者：
Jarkovska, Karla;Martinkova, Jirina;Kovarova, Hana
通讯作者：
Kovarova, Hana