Are Obese Patients with Autism Spectrum Disorder More Likely to Be Selenium Deficient? Research Findings on Pre- and Post-Pubertal Children.
Are Obese Patients with Autism Spectrum Disorder More Likely to Be Selenium Deficient? Research Findings on Pre- and Post-Pubertal Children.
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DOI：
10.3390/nu12113581
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发表时间：
2020-11-22
期刊：
影响因子：
5.9
通讯作者：
Skórzyńska-Dziduszko K
中科院分区：
文献类型：
--
作者：
Błażewicz A;Szymańska I;Dolliver W;Suchocki P;Turło J;Makarewicz A;Skórzyńska-Dziduszko K
硒参与了许多对生命至关重要的代谢途径。关于硒在自闭症谱系障碍（ASD）和肥胖中的代谢作用的信息仍然是相互矛盾和不完整的。ASD和肥胖患者青春期前后的硒谱尚未被调查。该研究的目的是检测被诊断为ASD的甲状腺功能正常儿童青春期前后的硒含量，与年龄匹配的神经正常对照组进行比较，超重或肥胖是共存的病理。采用电感耦合血浆质谱法测定287例青春期前儿童（平均年龄8.09岁）血清、脚趾甲和24小时尿硒水平，分为两组：ASD合并超重/肥胖（ASD+/Ob+）；无超重/肥胖的ASD (ASD+/Ob−)；非ASD伴超重/肥胖（ASD−/Ob+）；无超重/肥胖的非ASD （ASD−/Ob−）。对258名青春期后的儿童（平均年龄14.26岁）进行了重复评估。ASD+/Ob+患者青春期前后血清硒水平（p < 0.001）、尿液硒水平（p < 0.001）和脚趾甲硒水平（p < 0.001）最低，ASD - /Ob -患者青春期前后硒水平最高。ASD+/Ob -组和ASD - /Ob+组血清/趾甲硒水平无差异。在bmi匹配组中，ASD的存在与较低的血清硒（p < 0.001）和趾甲硒（p < 0.001）相关。在神经型患者中，青春期后血清硒水平低于青春期前（p < 0.001）。在多元线性回归分析中，硒水平与BMI （p < 0.001）和男性性别（p < 0.001）呈负相关，与样本类型无关。血清（p = 0.002）和脚趾甲（p < 0.001）硒水平与ASD的存在呈负相关。ASD、肥胖/超重和男性性别对儿童硒水平有独立的影响。青春期可能影响神经型儿童的硒含量，但对ASD患者没有影响。
Selenium is involved in many metabolic pathways that are critical for life. Information concerning the metabolic effects of selenium in autism spectrum disorder (ASD) and obesity is still conflicting and incomplete. The pre- and post-pubertal selenium profiles of patients with ASD and obesity have not yet been investigated. The goal of the study was to examine selenium content before and after puberty in euthyroid children diagnosed with ASD, compared to age-matched neurotypical controls, with respect to overweight or obesity as a co-existing pathology. Serum, toenail, and 24h urine selenium levels were determined by inductively coupled plasma mass spectrometry in 287 prepubertal children (mean age 8.09 years), divided into groups: ASD with overweight/obesity (ASD+/Ob+); ASD without overweight/obesity (ASD+/Ob−); non-ASD with overweight/obesity (ASD−/Ob+); and non-ASD without overweight/obesity (ASD−/Ob−). The assessment was repeated in 258 of the children after puberty (mean age 14.26 years).The lowest serum (p < 0.001), urine (p < 0.001) and toenail (p < 0.001) selenium levels before and after puberty were observed in ASD+/Ob+ patients, and the highest in ASD−/Ob−. There were no differences in serum/toenail selenium levels between ASD+/Ob− and ASD−/Ob+ groups. The presence of ASD was associatedwith lower serum (p < 0.001) and toenail (p < 0.001) selenium in BMI-matched groups. In neurotypical patients, post-pubertal serum selenium levels were lower (p < 0.001) than pre-pubertal levels. In the multiple linear regression analyses, selenium levels showed inverse relationships with BMI (p < 0.001) and male gender (p < 0.001), irrespective of the sample type. The serum (p = 0.002) and toenail (p < 0.001) selenium levels were inversely associated with the presence of ASD. ASD, obesity/overweight, and male gender have independent impacts on selenium levels in children. Puberty may affect selenium content in neurotypical children of both genders, but not in ASD patients.
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影响因子：
6.2
作者：
Long, Manhai;Ghisari, Mandana;Bonefeld-Jorgensen, Eva C.
通讯作者：
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影响因子：
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