Spinal and femoral bone mass accumulation during normal adolescence: comparison with female patients with sexual precocity and with hypogonadism.
Spinal and femoral bone mass accumulation during normal adolescence: comparison with female patients with sexual precocity and with hypogonadism.
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正常青春期脊柱和股骨骨量积累：与性早熟和性腺功能减退女性患者的比较。
DOI：
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发表时间：
1996
影响因子：
5.8
通讯作者：
Hiroo Niimi
中科院分区：
文献类型：
--
作者：
Yoshihito Takahashi;K. Minamitani;Y. Kobayashi;M. Minagawa;T. Yasuda;Hiroo Niimi
Since the attainment of higher bone mineral density (BMD) is a crucial strategy in preventing age-related bone loss and consequent fracture, we determined when bone mass of the lumbar spine (L2-L4) (g/cm2) and femoral neck (g/cm2) reaches its peak in healthy Japanese subjects and examined the influence of early exposure to estrogen and estrogen deficiency on BMD. We also determined the volumetric BMD, termed bone mineral apparent density (BMAD), of the lumbar spine and femoral neck. Using dual-energy x-ray absorptiometry (DXA) (Hologic QDR-1000), we measured BMD of both the lumbar spine and the femoral neck in 31 healthy children aged 2-11 yr, 269 children (138 males and 131 females) aged 13-19 yr, 12 men and 12 women aged 20-34 yr as adult controls, 11 patients with female central sexual precocity, and 3 patients with female primary hypogonadism. Because the densitometric data obtained from DXA are strongly influenced by the size of the bone in growing subjects, the volumetric BMAD (g/cm3) of the vertebral cube (L2-L4) and femoral neck were determined: BMAD (g/cm3) = BMD (g/cm2)/square root of scanned area (cm2) for the lumbar spine and by BMAD = BMD/width for the femoral neck. The BMD, both lumbar spine and femoral neck, nearly reached its peak at age 14.5-15 yr in girls and 16.5-17 yr in boys when compared with adult normal values. The difference in this age between sexes is identical to the difference in age at sexual maturation. BMD in patients with sexual precocity was high compared to age-matched controls, whereas patients with primary hypogonadism showed lower lumbar apparent BMD, and the increase in lumbar BMAD (g/cm3) was noted after the progression of puberty in healthy children, probably suggesting the importance of sex steroids in the increase of BMD and lumbar BMAD in both sexes. The girls with earlier menarche showed higher lumbar BMD at age 18 and 19 yr. For the femoral BMAD, there was no significant relationship between this value and age in girls. We conclude that peak bone mass is mainly achieved by late adolescence in Japanese as in Caucasians and that pubertal progression and probably estrogen itself play a crucial role in accumulation of bone mass in females.
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健康十二岁白人女性骨矿物质含量和骨密度的测量。
DOI：
--
发表时间：
1992
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Lloyd,T;Eggli,DF
通讯作者：
Eggli,DF
DOI：
10.1210/jcem.78.6.8200927
发表时间：
1994-06
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
F. Conte;M. Grumbach;Y. Ito;C. Fisher;E. Simpson
通讯作者：
F. Conte;M. Grumbach;Y. Ito;C. Fisher;E. Simpson
影响因子：
158.5
作者：
SMITH, EP;BOYD, J;KORACH, KS
通讯作者：
KORACH, KS
影响因子：
15.9
作者：
MATKOVIC, V;JELIC, T;HEANEY, RP
通讯作者：
HEANEY, RP
影响因子：
158.5
作者：
DRINKWATER, BL;NILSON, K;SOUTHWORTH, MB
通讯作者：
SOUTHWORTH, MB