A longitudinal study of measures of objective and subjective sleep disturbance in patients with breast cancer before, during, and after radiation therapy.
A longitudinal study of measures of objective and subjective sleep disturbance in patients with breast cancer before, during, and after radiation therapy.
复制标题
DOI：
10.1016/j.jpainsymman.2011.08.010
复制
发表时间：
2012-08
影响因子：
4.7
通讯作者：
Miaskowski, Christine
中科院分区：
文献类型：
--
作者：
Dhruva, Anand;Paul, Steven M.;Cooper, Bruce A.;Lee, Kathryn;West, Claudia;Aouizerat, Bradley E.;Dunn, Laura B.;Swift, Patrick S.;Wara, William;Miaskowski, Christine
关键词：
睡眠障碍是肿瘤患者的一个重要问题。研究在放射治疗（RT）过程中和放射治疗后，体动记录和自我报告的睡眠障碍评分如何变化;研究特定患者、疾病和症状特征是否可预测睡眠障碍的初始水平和/或轨迹特征;并比较主观和客观睡眠障碍的预测因素。患者（n=73）完成自我报告问卷，评估睡眠障碍，疲劳，抑郁症状，焦虑和疼痛开始RT之前，通过4个月后完成RT。腕动记录被用作睡眠障碍的客观措施。分层线性模型（HLM）用于数据分析。平均睡眠发作后觉醒（WASO）为11.9%，一般睡眠障碍量表（GSDS）的平均总分为45。超过85%的患者夜间觉醒次数异常多。睡眠障碍的客观和主观测量都存在显著的个体间差异。体重指数可预测客观睡眠障碍的基线水平。共病、夜间疲劳和抑郁症状可预测主观睡眠障碍的基线水平，抑郁症状可预测主观睡眠障碍的轨迹。不同的变量预测睡眠障碍的主观和客观的措施。当在大量夜间觉醒和患者对睡眠质量和数量差的感知的背景下进行评估时，发现WASO略微升高可能低估了睡眠障碍的程度。
Sleep disturbance is a significant problem in oncology patients. To examine how actigraphy and self-report ratings of sleep disturbance changed over the course of and following radiation therapy (RT); investigate whether specific patient, disease, and symptom characteristics predicted the initial levels and/or the characteristics of the trajectories of sleep disturbance; and to compare predictors of subjective and objective sleep disturbance. Patients (n=73) completed self-report questionnaires that assessed sleep disturbance, fatigue, depressive symptoms, anxiety, and pain prior to the initiation of RT through four months after the completion of RT. Wrist actigraphy was used as the objective measure of sleep disturbance. Hierarchical linear modeling (HLM) was used for data analyses. Mean wake after sleep onset (WASO) was 11.9% and mean total score on the General Sleep Disturbance Scale (GSDS) was 45. More than 85% of the patients had an abnormally high number of nighttime awakenings. Substantial interindividual variability was found for both objective and subjective measures of sleep disturbance. Body mass index predicted baseline levels of objective sleep disturbance. Comorbidity, evening fatigue, and depressive symptoms predicted baseline levels of subjective sleep disturbance, and depressive symptoms predicted the trajectory of subjective sleep disturbance. Different variables predicted sleep disturbance using subjective and objective measures. The slightly elevated WASO found may be an underestimation of the degree of sleep disturbance when it is evaluated in the context of the high number of nighttime awakenings and patient’s perception of poor sleep quality and quantity.
登录
查看更多内容
影响因子：
3.1
作者：
Beck, Susan L.;Berger, Ann M.;Barsevick, Andrea M.;Wong, Bob;Stewart, Katie A.;Dudley, William N.
通讯作者：
Dudley, William N.
影响因子：
5.6
作者：
LEE, KA
通讯作者：
LEE, KA
影响因子：
1.9
作者：
Berger, Ann M;Parker, Kathy P;Hall, Martica
通讯作者：
Hall, Martica
影响因子：
3.5
作者：
Kennedy, BL;Schwab, JJ;Beldia, G
通讯作者：
Beldia, G
影响因子：
11.3
作者：
LEE, KA;HICKS, G;NINOMURCIA, G
通讯作者：
NINOMURCIA, G