Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations.
Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations.
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DOI：
10.1016/j.mce.2021.111332
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发表时间：
2021-08-01
影响因子：
4.1
通讯作者：
Akingbemi, B. T.
中科院分区：
文献类型：
--
作者：
Jeminiwa, B. O.;Knight, R. C.;Abbot, K. L.;Pondugula, S. R.;Akingbemi, B. T.
环境中的化学物质会干扰内分泌轴，因此被归类为内分泌干扰物（EDCs）。双酚S（BPS）因其上级热稳定性而被用于消费品的生产，并被认为是其类似物双酚A（BPA）的安全替代化学品。然而，这些化合物单独或在其他EDCs存在下的安全性特征尚未得到充分研究。此外，供水中还含有雌激素化学物质17α-乙炔雌二醇（EE 2），是女性口服避孕药的一种成分。为了模拟同时暴露于化学混合物的人口，我们研究了BPA，BPS，EE 2，以及它们的组合对性类固醇分泌的影响，在不断增长的雄性大鼠性腺。向21日龄和35日龄的青春期前和青春期雄性大鼠提供饮用水中的试验化学品（十亿分之一），持续14天。在接触结束时，某些个别的化学效应因接触化学组合而改变。单一化学品暴露显著降低雄激素分泌，但它们的组合（例如，BPA+BPS+ EE 2）引起相反的效果，即，增加Leydig细胞T分泌。此外，供试化学品单独或联合作用可增加睾丸和Leydig细胞17β-雌二醇（E2）分泌。化学诱导的T和E2分泌变化与胆固醇侧链裂解（Cyp 11 a1）和17 β-羟基类固醇脱氢酶（Hsd 17 β）蛋白的睾丸表达改变相关。进一步的研究是必要的，以了解单一和化学组合影响睾丸细胞的功能和破坏其旁分泌调节的机制。
Environment chemicals can interfere with the endocrine axis hence they are classified as endocrine disrupting chemicals (EDCs). Bisphenol S (BPS) is used in the manufacture of consumer products because of its superior thermal stability and is thought to be a safe replacement chemical for its analog bisphenol A (BPA). However, the safety profile of these compounds alone or in the presence of other EDCs is yet to be fully investigated. Also, the estrogenic chemical 17α-ethinyl estradiol (EE2) and a constituent of female oral contraceptives for women is present in water supplies. To simulate concurrent exposure of the population to chemical mixtures, we investigated the effects of BPA, BPS, EE2, and their combinations on sex steroid secretion in the growing male rat gonad. Prepubertal and pubertal male rats at 21 and 35 days of age were provided test chemicals in drinking water (parts per billion) for 14 days. At termination of exposure, some individual chemical effects were modified by exposure to chemical combinations. Single chemical exposures markedly decreased androgen secretion but their combination (e.g., BPA+BPS+EE2) caused the opposite effect, i.e., increased Leydig cell T secretion. Also, the test chemicals acting alone or in combination increased testicular and Leydig cell 17β-estradiol (E2) secretion. Chemical-induced changes in T and E2 secretion were associated with altered testicular expression of the cholesterol side-chain cleavage (Cyp11a1) and 17 β-hydroxysteroid dehydrogenase (Hsd17β) enzyme protein. Additional studies are warranted to understand the mechanisms by which single and chemical combinations impact function of testicular cells and disrupt their paracrine regulation.
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双酚类似物对 H295R 细胞类固醇基因表达和激素合成的影响
影响因子：
8.8
作者：
Feng, Yixing;Jiao, Zhihao;Shao, Bing
通讯作者：
Shao, Bing
影响因子：
3.6
作者：
Clark, AM;Garland, KK;Russell, LD
通讯作者：
Russell, LD
影响因子：
10.4
作者：
Carpenter DO;Arcaro K;Spink DC
通讯作者：
Spink DC
DOI：
10.1016/b978-0-12-408134-5.00013-5
发表时间：
2014-01-01
期刊：
CELLULAR ENDOCRINOLOGY IN HEALTH AND DISEASE
影响因子：
--
作者：
Bremer, Andrew A.;Miller, Walter L.
通讯作者：
Miller, Walter L.
影响因子：
4.8
作者：
Akingbemi, BT;Sottas, CM;Hardy, MP
通讯作者：
Hardy, MP