Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors.
Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors.
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DOI：
10.1177/0963689717714102
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发表时间：
2017-07
影响因子：
3.3
通讯作者：
Zhao LR
中科院分区：
文献类型：
--
作者：
Galgano M;Toshkezi G;Qiu X;Russell T;Chin L;Zhao LR
创伤性脑损伤（TBI）表现为各种形式，从轻微的意识改变到持续的昏迷状态和死亡。在最严重的TBI形式中，整个大脑受到弥漫性损伤和肿胀的影响。治疗方式根据损伤的严重程度而有很大的不同，从日常认知治疗到根治性手术，如双侧去骨瓣减压术。已经制定了关于TBI最佳管理的指导方针，但必须根据具体情况加以考虑，不能在每一种情况下使用。本文从临床实践和基础研究两个方面对创伤性脑损伤的治疗现状进行了综述。我们已经提出了创伤性损伤的各种亚型，最佳的医疗管理，以及非侵入性和侵入性监测模式，除了在特定情况下必要的外科手术干预的简要概述。本文综述了近年来在基础科学领域寻找创伤性脑损伤治疗策略的主要成果。我们还从实验的角度讨论了TBI治疗的未来发展方向。
Traumatic brain injury (TBI) presents in various forms ranging from mild alterations of consciousness to an unrelenting comatose state and death. In the most severe form of TBI, the entirety of the brain is affected by a diffuse type of injury and swelling. Treatment modalities vary extensively based on the severity of the injury and range from daily cognitive therapy sessions to radical surgery such as bilateral decompressive craniectomies. Guidelines have been set forth regarding the optimal management of TBI, but they must be taken in context of the situation and cannot be used in every individual circumstance. In this review article, we have summarized the current status of treatment for TBI in both clinical practice and basic research. We have put forth a brief overview of the various subtypes of traumatic injuries, optimal medical management, and both the noninvasive and invasive monitoring modalities, in addition to the surgical interventions necessary in particular instances. We have overviewed the main achievements in searching for therapeutic strategies of TBI in basic science. We have also discussed the future direction for developing TBI treatment from an experimental perspective.
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