Electric Field Comparison between Microelectrode Recording and Deep Brain Stimulation Systems-A Simulation Study.
Electric Field Comparison between Microelectrode Recording and Deep Brain Stimulation Systems-A Simulation Study.
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DOI：
10.3390/brainsci8020028
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发表时间：
2018-02-06
期刊：
影响因子：
3.3
通讯作者：
Hemm S
中科院分区：
文献类型：
--
作者：
Alonso F;Vogel D;Johansson J;Wårdell K;Hemm S
深部脑刺激（DBS）的成功主要依赖于植入电极的定位。其最终位置可以根据术中微电极记录（MER）和刺激测试的结果来选择。最佳位置通常与 DBS 电极慢性刺激的最终选择位置不同。该研究的目的是使用有限元法 (FEM) 建模和模拟来调查引线设计、电气设置和操作模式是否会引起电场 (EF) 分布的差异，从而影响临床结果。开发了 MER 系统和慢性 DBS 导联的有限元模型。对同质和患者特异性脑模型进行 EF 模拟，以评估接地（导管与刺激器情况）、平行 MER 引线和非活动 DBS 接触的影响。结果表明，EF 的变形取决于导管和刺激接触之间的距离。多个并行 MER 引线和非活动 DBS 触点的存在会影响 EF 分布。 DBS EF 体积可以覆盖术中产生的 EF，但也可以扩展到其他解剖区域。总之，应考虑刺激测试和 DBS 之间的 EF 变形，因为它们可以改变临床结果。
The success of deep brain stimulation (DBS) relies primarily on the localization of the implanted electrode. Its final position can be chosen based on the results of intraoperative microelectrode recording (MER) and stimulation tests. The optimal position often differs from the final one selected for chronic stimulation with the DBS electrode. The aim of the study was to investigate, using finite element method (FEM) modeling and simulations, whether lead design, electrical setup, and operating modes induce differences in electric field (EF) distribution and in consequence, the clinical outcome. Finite element models of a MER system and a chronic DBS lead were developed. Simulations of the EF were performed for homogenous and patient-specific brain models to evaluate the influence of grounding (guide tube vs. stimulator case), parallel MER leads, and non-active DBS contacts. Results showed that the EF is deformed depending on the distance between the guide tube and stimulating contact. Several parallel MER leads and the presence of the non-active DBS contacts influence the EF distribution. The DBS EF volume can cover the intraoperatively produced EF, but can also extend to other anatomical areas. In conclusion, EF deformations between stimulation tests and DBS should be taken into consideration as they can alter the clinical outcome.
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