The influence of reactivity of the electrode-brain interface on the crossing electric current in therapeutic deep brain stimulation.
The influence of reactivity of the electrode-brain interface on the crossing electric current in therapeutic deep brain stimulation.
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DOI：
10.1016/j.neuroscience.2008.07.051
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发表时间：
2008-10-15
期刊：
影响因子：
3.3
通讯作者：
Liu, X.
中科院分区：
文献类型：
--
作者：
Yousif, N.;Bayford, R.;Liu, X.
由于缺乏对观察到的患者临床改善的机制的理解，深部脑刺激（DBS）作为许多神经系统疾病的有效临床治疗方法的使用受到了极大的阻碍。由于难以在原位研究DBS对神经元的影响，以及不可能在体内测量感应电流，使这个问题复杂化。在我们最近使用准静态有限元（FEM）模型的计算工作中，我们定量地表明深度电极脑界面（EBI）的性质对DBS电极周围脑体积中诱导的电场有显著影响。在目前的工作中，我们利用傅里叶-有限元方法探讨了EBI的反应性对交叉电流的影响，以便在时域内研究波形衰减。结果表明，在植入后的不同阶段，EBI对波形形成的影响不同，这反过来又影响了整个EBI的感应电流分布。此外，我们研究了假设波形是否比目前使用的方形脉冲有任何优势，这些波形被证明对神经刺激有潜在的用处，但尚未在临床上应用。综上所述，EBI的反应性对治疗性DBS中交叉刺激电流的影响是显著的，并影响了对植入脑深部电刺激电极周围电流分布的预测估计。
The use of deep brain stimulation (DBS) as an effective clinical therapy for a number of neurological disorders has been greatly hindered by the lack of understanding of the mechanisms which underlie the observed clinical improvement in patients. This problem is confounded by the difficulty of investigating the neuronal effects of DBS in situ, and the impossibility of measuring the induced current in vivo. In our recent computational work using a quasi-static finite element (FEM) model we have quantitatively shown that the properties of the depth electrode brain interface (EBI) have a significant effect on the electric field induced in the brain volume surrounding the DBS electrode. In the present work, we explore the influence of the reactivity of the EBI on the crossing electric current using the Fourier-FEM approach to allow the investigation of waveform attenuation in the time domain. Results showed that the EBI affected the waveform shaping differently at different post-implantation stages, and that this in turn had implications on induced current distribution across the EBI. Furthermore, we investigated whether hypothetical waveforms, which were shown to have potential usefulness for neural stimulation but are not yet applied clinically, would have any advantage over the currently used square pulse. In conclusion, the influence of reactivity of the EBI on the crossing stimulation current in therapeutic DBS is significant, and affects the predictive estimation of current distribution around the implanted DBS electrode in the human brain.
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影响因子：
2.8
作者：
Van Kuyck, Kris;Welkenhuysen, Marleen;Nuttin, Bart
通讯作者：
Nuttin, Bart
影响因子：
2.8
作者：
Hemm, S;Vayssiere, N;Coubes, P
通讯作者：
Coubes, P
影响因子：
5.1
作者：
Nielsen, M. S.;Bjarkam, C. R.;Ostergaard, K.
通讯作者：
Ostergaard, K.
影响因子：
3.8
作者：
Priori, A.;Ardolino, G.;Foffani, G.
通讯作者：
Foffani, G.
DOI：
10.1088/0143-0815/8/4a/002
发表时间：
1987-01-01
期刊：
Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics
影响因子：
--
作者：
Pethig, R
通讯作者：
Pethig, R