Association of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity.
Association of cerebral networks in resting state with sexual preference of homosexual men: a study of regional homogeneity and functional connectivity.
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静息状态下的大脑网络与同性恋男性性偏好的关联：区域同质性和功能连接性的研究
DOI：
10.1371/journal.pone.0059426
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Hu S;Xu D;Peterson BS;Wang Q;He X;Hu J;Xu X;Wei N;Long D;Huang M;Zhou W;Xu W;Zhang M;Xu Y
最近的影像学研究表明，同性恋和异性恋男性在性唤起时的大脑形态和神经活动是不同的。然而，神经网络在静息状态下的功能差异是未知的。该研究旨在描述同性恋偏好与静息状态下的区域同质性和功能连通性的关系。研究对象为26名健康男同性恋者和26名年龄匹配的健康异性恋者，收集静息状态下的回波平面磁共振成像数据。性取向采用金赛量表进行评估。我们首先评估了区域同质性的群体差异，然后，将识别的差异作为种子区域，我们比较了这些种子的功能连通性。通过检查区域同质性和功能连通性差异与金赛分数的关联来评估其行为意义。同性恋者的左枕下回、右枕中回、右枕上回、左楔叶、右楔前叶区域均匀性显著降低，直肠回、双侧中脑和左颞叶区域均匀性显著增加。左侧枕下回的区域均一性与Kinsey评分呈正相关。同性恋组的左颞中回、左边缘上回、右楔叶与种子区（即左枕下回）之间的功能连通性也有所降低。此外，左侧枕下回与右侧丘脑的连接与Kinsey评分呈正相关。这些区域同质性和功能连通性的差异可能有助于更好地理解男性性取向的神经基础。
Recent imaging studies have shown that brain morphology and neural activity during sexual arousal differ between homosexual and heterosexual men. However, functional differences in neural networks at the resting state is unknown. The study is to characterize the association of homosexual preference with measures of regional homogeneity and functional connectivity in the resting state. Participants were 26 healthy homosexual men and 26 age-matched healthy heterosexual men in whom we collected echo planar magnetic resonance imaging data in the resting state. The sexual orientation was evaluated using the Kinsey Scale. We first assessed group differences in regional homogeneity and then, taking the identified differences as seed regions, we compared groups in measures of functional connectivity from those seeds. The behavioral significances of the differences in regional homogeneity and functional connectivity were assessed by examining their associations with Kinsey Scores. Homosexual participants showed significantly reduced regional homogeneity in the left inferior occipital gyrus, right middle occipital gyrus, right superior occipital gyrus, left cuneus, right precuneus, and increased regional homogeneity in rectal gyrus, bilateral midbrain, and left temporal lobe. Regional homogeneity correlated positively with Kinsey scores in the left inferior occipital gyrus. The homosexual group also showed reduced functional connectivity between left middle temporal gyrus, left supra-marginal gyrus, right cuneus and the seed region, i.e. left inferior occipital gyrus. Additionly, the connection between the left inferior occipital gyrus and right thalamus correlated positively with Kinsey scores. These differences in regional homogeneity and functional connectivity may contribute to a better understanding of the neural basis of male sexual orientation.
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DOI：
10.1073/pnas.89.15.7199
发表时间：
1992-08-01
影响因子：
11.1
作者：
ALLEN, LS;GORSKI, RA
通讯作者：
GORSKI, RA
DOI：
10.1073/pnas.95.15.8939
发表时间：
1998-07-21
影响因子：
11.1
作者：
Horwitz, B;Rumsey, JM;Donohue, BC
通讯作者：
Donohue, BC
影响因子：
2.5
作者：
Hubrich-Ungureanu, P;Kaemmerer, N;Braus, DF
通讯作者：
Braus, DF
影响因子：
4.8
作者：
Friston, Karl J.
通讯作者：
Friston, Karl J.
DOI：
10.1111/j.1529-1006.2007.00032.x
发表时间：
2007-08-01
影响因子：
--
作者：
Halpern, Diane F;Benbow, Camilla P;Gernsbacher, Morton Ann
通讯作者：
Gernsbacher, Morton Ann