Transforming growth factor-β (TGF-β) expression is increased in the subsynovial connective tissues of patients with idiopathic carpal tunnel syndrome.
Transforming growth factor-β (TGF-β) expression is increased in the subsynovial connective tissues of patients with idiopathic carpal tunnel syndrome.
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DOI：
10.1002/jor.22485
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发表时间：
2014-01
影响因子：
2.8
通讯作者：
Amadio, Peter C.
中科院分区：
文献类型：
--
作者：
Chikenji, Takako;Gingery, Anne;Zhao, Chunfeng;Passe, Sandra M.;Ozasa, Yasuhiro;Larson, Dirk;An, Kai-Nan;Amadio, Peter C.
滑膜下结缔组织（SSCT）的非炎性纤维化是腕管综合征（CTS）的标志。这一发现的病因及其与CTS发展的关系仍然知之甚少。最近的研究发现，转化生长因子-β (TGF-β)在纤维化中起着核心作用。本研究旨在探讨TGF-β和TGF-β下游介质结缔组织生长因子（CTGF）在CTS发病机制中的表达。我们比较了26例特发性CTS患者的SSCT标本与10例既往无CTS诊断的人尸体标本。免疫组化检测TGF-β1、CTGF、胶原1（Col1）、胶原3 （Col3）表达水平。CTS患者SSCT中TGF-β1（P<0.01）、CTGF （P<0.01）、Col3 （P<0.01）均较对照组织升高。此外，TGF-β1与CTGF呈强正相关（R2=0.80, p<0.01）， Col3与TGF-β1呈中度正相关（R2=0.49, p<0.01）。这些发现表明，TGF-β和CTGF（一种TGF-β调节蛋白）的表达增加，这种TGF-β激活可能是CTS患者SSCT纤维化的原因。
Non-inflammatory fibrosis of the subsynovial connective tissue (SSCT) is a hallmark of carpal tunnel syndrome (CTS). The etiology of this finding and its relationship to the development of CTS remain poorly understood. Recent studies have found that transforming growth factor-β (TGF-β) plays a central role in fibrosis. The purpose of this study was to investigate the expression of TGF-β and connective tissue growth factor (CTGF), a downstream mediator of TGF-β, in the pathogenesis of CTS. We compared SSCT specimens from 26 idiopathic CTS patients with specimens from 10 human cadaver controls with no previous diagnosis of CTS. Immunohistochemistry was performed to determine levels TGF-β1, CTGF, collagen 1(Col1) and collagen 3 (Col3) expression. TGF-β1(P<0.01), CTGF (P<0.01), and Col3 (P<0.01) were increased in SSCT of CTS patients compared with control tissue. In addition, a strong positive correlation was found between TGF-β1 and CTGF, (R2=0.80, p<0.01) and a moderate positive correlation between Col3 and TGF-β1 (R2=0.49, p<0.01). These finding suggest that there is an increased expression of TGF-β and CTGF, a TGF-β regulated protein, and that this TGF-β activation may be responsible for SSCT fibrosis in CTS patients.
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影响因子：
1.9
作者：
FUCHS, PC;NATHAN, PA;MYERS, LD
通讯作者：
MYERS, LD
影响因子：
6.5
作者：
Frazier, K;Williams, S;Grotendorst, GR
通讯作者：
Grotendorst, GR
影响因子：
3.8
作者：
Demirkol, Ahmet;Uludag, Murat;Kesiktas, Fatma Nur
通讯作者：
Kesiktas, Fatma Nur
DOI：
10.1083/jcb.114.6.1285
发表时间：
1991-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bradham DM;Igarashi A;Potter RL;Grotendorst GR
通讯作者：
Grotendorst GR
影响因子：
3.9
作者：
Gauldie, J.;Bonniaud, P.;Kolb, M.
通讯作者：
Kolb, M.