Periostin is up-regulated in high grade and high stage prostate cancer.
Periostin is up-regulated in high grade and high stage prostate cancer.
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DOI：
10.1186/1471-2407-10-273
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发表时间：
2010-06-09
期刊：
影响因子：
3.8
通讯作者：
Kristiansen G
中科院分区：
文献类型：
--
作者：
Tischler V;Fritzsche FR;Wild PJ;Stephan C;Seifert HH;Riener MO;Hermanns T;Mortezavi A;Gerhardt J;Schraml P;Jung K;Moch H;Soltermann A;Kristiansen G
骨膜蛋白的表达是癌症中上皮-间充质转化的指标，但到目前为止尚未进行前列腺癌中骨膜蛋白表达的详细分析。在这里，我们在两个独立的前列腺癌队列中，包括训练队列（n = 93）和测试队列（n = 325），以化学方法评估了前列腺癌细胞和肿瘤周围基质中的骨膜蛋白表达。还分析了转移性前列腺癌（n = 20）、激素难治性前列腺癌（n = 19）和良性前列腺组织（n = 38）。总的来说，在418例前列腺癌中的142例（34.0%）和38例良性前列腺腺体中的11例（28.9%）中可检测到强上皮骨膜蛋白表达。在测试组群中，癌细胞中骨膜蛋白表达的增加与高Gleason评分（p < 0.01）和晚期肿瘤分期（p < 0.05）显著相关。而骨膜蛋白的表达是弱的或不存在的正常前列腺腺体周围的基质中，强骨膜蛋白的表达在肿瘤间质中被发现在大多数原发性和转移性前列腺癌。高基质骨膜蛋白表达与较高的Gleason评分相关（p < 0.001）。在训练队列中，基质骨膜蛋白表达与PSA无复发生存时间缩短之间存在关系（p < 0.05）。我们的数据表明，骨膜蛋白上调与前列腺癌中肿瘤侵袭性增加有关，可能是原发性和转移性前列腺癌治疗干预的有希望的靶点。
Expression of periostin is an indicator of epithelial-mesenchymal transition in cancer but a detailed analysis of periostin expression in prostate cancer has not been conducted so far. Here, we evaluated periostin expression in prostate cancer cells and peritumoural stroma immunohistochemically in two independent prostate cancer cohorts, including a training cohort (n = 93) and a test cohort (n = 325). Metastatic prostate cancers (n = 20), hormone refractory prostate cancers (n = 19) and benign prostatic tissues (n = 38) were also analyzed. In total, strong epithelial periostin expression was detectable in 142 of 418 (34.0%) of prostate carcinomas and in 11 of 38 benign prostate glands (28.9%). Increased periostin expression in carcinoma cells was significantly associated with high Gleason score (p < 0.01) and advanced tumour stage (p < 0.05) in the test cohort. Whereas periostin expression was weak or absent in the stroma around normal prostate glands, strong periostin expression in tumour stroma was found in most primary and metastatic prostate cancers. High stromal periostin expression was associated with higher Gleason scores (p < 0.001). There was a relationship between stromal periostin expression and shortened PSA relapse free survival times in the training cohort (p < 0.05). Our data indicate that periostin up-regulation is related to increased tumour aggressiveness in prostate cancer and might be a promising target for therapeutical interventions in primary and metastatic prostate cancer.
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影响因子：
7
作者：
Castronovo, Vincent;Waltregny, David;Neri, Dario
通讯作者：
Neri, Dario
影响因子：
7.5
作者：
Fukushima, Noriyoshi;Kikuchi, Yoshinao;Fukayama, Masashi
通讯作者：
Fukayama, Masashi
影响因子：
6.4
作者：
Kanno, Atsushi;Satoh, Kennichi;Shimosegawa, Tooru
通讯作者：
Shimosegawa, Tooru
影响因子：
4
作者：
Oshima, A;Tanabe, H;Kudo, A
通讯作者：
Kudo, A
影响因子：
50.3
作者：
Bao, SD;Ouyang, G;Wang, XF
通讯作者：
Wang, XF